Figure 4

Promoter variant luciferase activity in various cell lines. Promoter variant luciferase activity measured in MCF7 (a) and HepG2 (b) cells. Cells were transfected either with UGT1A4 common allele promoter or with promoters with single variants at -163, -217, and -219 and with a promoter with all three variant (complete variant). Cells were then treated with 10 mM fulvestrant and luciferase activity was measured, and is displayed as percentage difference * p value < 0.01, Δ p value ≤ 0.01.