Table 3 Amino acid residues in β1, β2, β5 catalytic subunits in yeast 20S proteasome (PDB code: 2F16:N,H,K-chains, respectively) and equivalent residues (substitutions) in Pf 20S proteasome associated with the catalytic sites, substrate binding pockets, maintenance of stability of Thr1 and interactions with the bortezomib inhibitor
Residue Number | Catalytic subunits | ||
|---|---|---|---|
β1 | β2 | β5 | |
1 | T | T | T |
17 | D | D | D |
20 | T | S(A) | A |
21 | T(S) | T | T(S) |
22 | T(S) | Q(E) | A(M) |
31 | T(S) | C | V |
33 | K | K | K |
35 | T(N) | H | I |
45 | R | G | M |
47 | G | G | G |
49 | A(S) | A | A |
53 | Q | E | Q(L) |
129 | S | S | S |
166 | D | D | D |
169 | S | S | S |