Human GMDS gene fragment hypermethylation in chronic high level of arsenic exposure with and without arsenic induced cancer

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Table 1 Demographic data of study subjects taken from different arsenic exposure groups

Age group	Sex	Group A (0-50 μg/l) p53 methylation	Group C (250-500 μg/l) p53 methylation	Group D (501-1000 μg/l) p53 methylation	Group E (500-1100 μg/l) p53 methylation
<20 years	Male	N = 2; 0.08, 0.19	N = 2; 1.34, 1.62
<20 years	Female	N = 2; 0.08, 0.19	N = 2; 1.50, 1.45
21-40 years	Male	N = 3; 0.03, 0.23, 0.15	N = 3; 1.50, 2.78, 5.00	N = 4; 1.95, 2.04, 4.3 2.46	N = 3; 0.85, 1.09, 1.32
21-40 years	Female	N = 1; 0.15		N = 1; 2.56	N = 3; 1.00, 1.62, 1.09
41-60 years	Male	N = 3;0.18, 0.27, 0.27	N = 2; 1.56, 2.4	N = 2; 2.85, 4.46	N = 4; 1.42, 3.08, 2.09, 2.09
41-60 years	Female	N = 3; 0.08, 0.09, 0.32	N = 2; 1.95, 4.66	N = 2 4.45, 2.7	N = 1; 2.55
>60 years	Male			N = 1; 2.15	N = 4; 2.20, 2.23, 1.62, 1.60
>60 years	Female				N = 1; 2.11
Smoking status	Smoker	8	9	7	11
	Nonsmoker	4	2	3	5
	Exsmoker
Avarage duration of exposure		11.5 years	15 years	10 years	17 years
Total number of samples	47/M	12	11	10	16

Note: numerical values in each cell indicate the degree of p53 methylation for individual study subjects recruited in the study.