Table 1 Disintegration rates of brand alendronate and generic alendronate
From: A critical review of brand and generic alendronate for the treatment of osteoporosis
Lead author, year | Brand or generic | Dose | Trade or Manufacturer name | Country of origin | n | Dsnt time (s) (mean) | Dsnt time (s) (sd) | % RSD | Dsnt < 30s |
|---|---|---|---|---|---|---|---|---|---|
Epstein, 2003 | Brand | 70mg | Fosamax, Merck & Co., Inc. | US | 27 | 86.1 | 11.8 | 14% | N |
| Â | Generic | 70mg | Fosval | Chile | 12 | 6.9 | 1.5 | 23% | Y |
| Â | Generic | 70mg | Osteoplus | Ecuador | 12 | 14.7 | 1.6 | 11% | Y |
| Â | Generic | 70mg | Fixopan | Ecuador | 14 | 16.2 | 2.1 | 13% | Y |
| Â | Generic | 70mg | Osteomix | Ecuador | 12 | 22.4 | 2.1 | 9% | Y |
| Â | Generic | 70mg | Genalmen | Venezuela | 8 | 26.1 | 1.9 | 7% | Y |
| Â | Generic | 70mg | Genalmen | Venezuela | 4 | 19.5 | 3.1 | 16% | Y |
| Â | Generic | 70mg | Endronax | Brazil | 12 | 32.8 | 4.7 | 15% | N |
| Â | Generic | 70mg | Osteomax | Costa Rica | 13 | 44.2 | 3.7 | 8% | N |
| Â | Generic | 70mg | Fosmin | Peru | 10 | 46.5 | 11.6 | 25% | N |
| Â | Generic | 70mg | Defixal | Venezuela | 12 | 46.5 | 4.4 | 10% | N |
| Â | Generic | 70mg | Ostenan | Brazil | 14 | 25.0 | 11.2 | 45% | Y |
| Â | Generic | 70mg | Regenesis | Argentina | 20 | 13.0 | 1.7 | 13% | Y |
| Â | Generic | 70mg | Neobon | Columbia | 23 | 13.0 | 6.7 | 52% | Y |
Dansereau, 2008 | Brand | 70mg | Fosamax, Merck & Co., Inc. "A" | US | 4-6 | 43 | 11 | 26% | N |
| Â | Brand | 70mg | Fosamax, Merck & Co., Inc. "B" | US | 4-6 | 78 | 12 | 15% | N |
| Â | Brand | 70mg | Fosamax, Merck & Co., Inc. "C" | US | 4-6 | 52 | 23 | 44% | N |
| Â | Brand | 35mg | Actonel, P&G Pharmaceuticals "A" | US | 4-6 | 35 | 3 | 9% | N |
| Â | Brand | 35mg | Actonel, P&G Pharmaceuticals "B" | US | 4-6 | 44 | 7 | 16% | N |
| Â | Brand | 35mg | Actonel, P&G Pharmaceuticals "C" | US | 4-6 | 49 | 6 | 12% | N |
| Â | Generic | 70mg | Apotex "A" | Canada | 4-6 | 198 | 78 | 39% | N |
| Â | Generic | 70mg | Apotex "B" | Canada | 4-6 | 132 | 48 | 36% | N |
| Â | Generic | 70mg | Apotex "C" | Canada | 4-6 | 192 | 48 | 25% | N |
| Â | Generic | 70mg | Cobalt "A" | Canada | 4-6 | 150 | 42 | 28% | N |
| Â | Generic | 70mg | Cobalt "B" | Canada | 4-6 | 174 | 48 | 28% | N |
| Â | Generic | 70mg | Novopharm "A" | Canada | 4-6 | 21 | 7 | 33% | Y |
| Â | Generic | 70mg | Novopharm "B" | Canada | 4-6 | 13 | 1 | 8% | Y |
| Â | Generic | 70mg | Novopharm "C" | Canada | 4-6 | 24 | 50 | 208% | Y |
| Â | Generic | 70mg | Pharmascience | Canada | 4-6 | 126 | 48 | 38% | N |
Dansereau, 2009 | Brand | 70mg | Fosamax, Merck & Co., Inc. | US | 6 | 53 | 9 | 17% | N |
| Â | Generic | 70mg | Teva Pharma "A" | US | 6 | 60 | 24 | 40% | N |
| Â | Generic | 70mg | Teva Pharma "B" | US | 6 | 27 | 3 | 11% | Y |
| Â | Generic | 70mg | Teva Pharma "C" | US | 6 | 72 | 6 | 8% | N |
| Â | Generic* | 70mg | Watson Pharma | US | 6 | 108 | 42 | 39% | N |
| Â | Generic | 70mg | Barr Laboratories, Inc "A" | US | 6 | 10 | 2 | 20% | Y |
| Â | Generic | 70mg | Barr Laboratories, Inc "B" | US | 6 | 9 | 1 | 11% | Y |
| Â | Generic | 70mg | Barr Laboratories, Inc "C" | US | 6 | 9 | 2 | 22% | Y |
| Â | Generic | 70mg | Aluid | Germany | 4-6 | 84 | 18 | 21% | N |
| Â | Generic | 70mg | AWD | Germany | 4-6 | 168 | 18 | 11% | N |
| Â | Generic | 70mg | Betapharm "A" | Germany | 4-6 | 342 | 96 | 28% | N |
| Â | Generic | 70mg | Betapharm "B" | Germany | 4-6 | 156 | 42 | 27% | N |
| Â | Generic | 70mg | Betapharm "C" | Germany | 4-6 | 174 | 48 | 28% | N |
| Â | Generic | 70mg | GRY | Germany | 4-6 | 21 | 5 | 24% | Y |
| Â | Generic | 70mg | Hexal "A" | Germany | 4-6 | 336 | 66 | 20% | N |
| Â | Generic | 70mg | Hexal "B" | Germany | 4-6 | 60 | 6 | 10% | N |
| Â | Generic | 70mg | Hexal "C" | Germany | 4-6 | 150 | 54 | 36% | N |
| Â | Generic | 70mg | Heuman | Germany | 4-6 | 168 | 24 | 14% | N |
| Â | Generic | 70mg | Juta | Germany | 4-6 | 30 | 4 | 13% | N |
| Â | Brand | 70mg | Fosamax, Merck & Co., Inc. | Germany | 4-6 | 84 | 18 | 21% | N |
| Â | Generic | 70mg | Ratiopharm "A" | Germany | 4-6 | 84 | 24 | 29% | N |
| Â | Generic | 70mg | Ratiopharm "B" | Germany | 4-6 | 246 | 42 | 17% | N |
| Â | Generic | 70mg | Ratiopharm "C" | Germany | 4-6 | 198 | 36 | 18% | N |
| Â | Generic | 70mg | Stada "A" | Germany | 4-6 | 186 | 84 | 45% | N |
| Â | Generic | 70mg | Stada "B" | Germany | 4-6 | 186 | 96 | 52% | N |
| Â | Generic | 70mg | Stada "C" | Germany | 4-6 | 222 | 24 | 11% | N |
| Â | Generic | 70mg | Apothecon | Netherlands | 4-6 | 106 | 30 | 28% | N |
| Â | Generic | 70mg | Kromme | Netherlands | 4-6 | 58 | 14 | 24% | N |
| Â | Generic | 70mg | Centrapharm | Netherlands | 4-6 | 330 | 60 | 18% | N |
| Â | Generic | 70mg | Pharmachemie | Netherlands | 4-6 | 14 | 4 | 29% | Y |
| Â | Generic | 70mg | Ratiopharm | Netherlands | 4-6 | 66 | 18 | 27% | N |
| Â | Generic | 70mg | Sandoz | Netherlands | 4-6 | 72 | 30 | 42% | N |
| Â | Generic | 70mg | APS/Teva "A" | UK | 4-6 | 37 | 9 | 24% | N |
| Â | Generic | 70mg | APS/Teva "B" | UK | 4-6 | 26 | 5 | 19% | Y |
| Â | Generic | 70mg | Arrow "A" | UK | 4-6 | 144 | 60 | 42% | N |
| Â | Generic | 70mg | Arrow "B" | UK | 4-6 | 34 | 9 | 26% | N |
| Â | Generic | 70mg | Pliva | UK | 4-6 | 60 | 12 | 20% | N |
| Â | Generic | 70mg | Ratiopharm | UK | 4-6 | 78 | 18 | 23% | N |
| Â | Generic | 70mg | Teva "A" | UK | 4-6 | 14 | 3 | 21% | Y |
| Â | Generic | 70mg | Teva "B" | UK | 4-6 | 29 | 5 | 17% | Y |
| Â | Generic | 70mg | Winthrop "A" | UK | 4-6 | 132 | 36 | 27% | N |
| Â | Generic | 70mg | Winthrop "B" | UK | 4-6 | 306 | 36 | 12% | N |