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Table 4 Dose response relationship of the urinary cadmium (4 levels) and renal dysfunction biomarkers of the subjects

From: Use of the kidney injury molecule-1 as a biomarker for early detection of renal tubular dysfunction in a population chronically exposed to cadmium in the environment

Cadmium

N

KIM-1

NAG

β2-MG

(μg/g Cr)

 

(pg/g Cr)

(U/g Cr)

(μg/g Cr)

Men

    

   < 2

13

513.9 (2.2)

4.0 (2.2)

137.1 (5.0)

  2–4.99

67

686.8 (2.2)

4.5 (1.8)

266.2 (9.4)

  5–9.99

118

863.2 (2.2)*

5.0 (1.7)

345.0 (8.9)

   ≥ 10

62

1211.2 (2.1)**

7.5 (2.0)**

721.3 (10.5)*

Women

    

   < 2

23

711.9 (2.0)

3.8 (2.1)

61.4 (3.4)

  2–4.99

95

922.4 (2.2)

5.1 (1.8)

175.1 (5.6)*

  5–9.99

201

1040.9 (2.2)

5.5 (1.7)*

160.9 (5.9)*

   ≥ 10

121

1269.4 (2.4)**

7.1 (1.9)***

294.8 (6.7)***

  1. N: number of subjects; KIM-1: kidney injury molecule-1; NAG: N-acetyl-β-D-glucosaminidase; β2-MG: β2−microglobulin.
  2. *P<0.05; **P<0.01; ***P<0.001: significant different from the subjects group with cadmium concentrations below 2 μg/gCr (Dunnet T test for post hock).
  3. Values of renal markers represent geometrical mean (geometrical standard deviation).