CYP2D6 Genotype | Gene-dose effect | ||||
---|---|---|---|---|---|
Tamoxifen and Metabolites | All (N = 224) | Normal (N = 34) | Intermediate (N = 107) | Slow (N = 83) | Variance explained (p-value for trend) |
Tamoxifen (TAM) | 195.3 ± 240.9 | 207.7 ± 256.7 | 167.7 ± 150.5 | 226.1 ± 316.2 | 0.003 (0.39) |
NDMTAM | 353.3 ± 409.0 | 325.5 ± 371.1 | 297.0 ± 238.5 | 437.2 ± 560.6 | 0.016 (0.060) |
Endoxifen | 35.4 ± 28.7 | 48.2 ± 39.7 | 39.3 ± 26.6 | 25.0 ± 22.3 | 0.086 (<0.0001) |
4-OHTAM | 1.9 ± 1.5 | 2.2 ± 1.8 | 1.9 ± 1.2 | 1.7 ± 1.7 | 0.010 (0.13) |