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Table 3 Tamoxifen and metabolites concentrations* in patients with CYP2D6 in 224 Filipino and Vietnamese patients

From: CYP2D6 genotypes, endoxifen levels, and disease recurrence in 224 Filipino and Vietnamese women receiving adjuvant tamoxifen for operable breast cancer

 

CYP2D6 Genotype

Gene-dose effect

Tamoxifen and Metabolites

All (N = 224)

Normal (N = 34)

Intermediate (N = 107)

Slow (N = 83)

Variance explained (p-value for trend)

Tamoxifen (TAM)

195.3 ± 240.9

207.7 ± 256.7

167.7 ± 150.5

226.1 ± 316.2

0.003 (0.39)

NDMTAM

353.3 ± 409.0

325.5 ± 371.1

297.0 ± 238.5

437.2 ± 560.6

0.016 (0.060)

Endoxifen

35.4 ± 28.7

48.2 ± 39.7

39.3 ± 26.6

25.0 ± 22.3

0.086 (<0.0001)

4-OHTAM

1.9 ± 1.5

2.2 ± 1.8

1.9 ± 1.2

1.7 ± 1.7

0.010 (0.13)

  1. *Concentrations (+/− S.D.) are all in ng/ml.