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Figure 2 | SpringerPlus

Figure 2

From: Presence of anaplastic lymphoma kinase in inflammatory breast cancer

Figure 2

FISH analysis of ALK genetic abnormalities in IBC patient tumors and Levels of ALK Gene Expression in Breast Tumors. A. Immunofluorescence image of FISH analysis of IBC tumor showing heterogeneity of ALK copy number, varying from 3–8 copies of ALK. B. Immunofluorescence image of FISH analysis of IBC tumor showing one of the two fusion signals separated as one red and one green signal in 76% of nuclei scored, consistent with the presence of EML4-ALK translocation (arrows). C. The posterior probabilities of samples to be classified as "IBC-like" in function associated with ALK copy number alterations (CNAs) are shown in boxplot-format. All observed differences were statistically significant (P ≤ 0.010). There was a positive and significant association between breast tumor samples classified as basal-like with IBC characteristics and ALK copy number alterations.

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