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Table 2 Peritransplant outcomes

From: Comparison of BEAM vs. LEAM regimen in autologous transplant for lymphoma at AIIMS

High dose chemotherapy regimen

 

BEAM (n = 34)

LEAM (n= 17)

 
 

N

%

N

%

p

Engraftment (days)*

   

 Neutrophil engraftment

12 (8 – 41)

15 (10 – 25)

0.090

 Platelet engraftment

18.5 (10 – 37)

22 (12 – 35)

0.199

Febrile neutropenia

    

0.806

 FUO (Fever of unknown origin)

9

26.5

6

35.3

 MDI (microbiologically documented infection)

14

41.2

6

35.3

 CDI (Clinically documented infection)

11

32.3

5

29.4

Antibiotic days *

13 (5 – 57)

18 (12 – 27)

0.185

Antibiotic number†

4.9 ± 1.6

5.7 ± 2.3

0.157

Regimen related Organ toxicities

     

 Oral mucositis (Grade 3/4)

23

68

11

65

0.834

 Diarrhea (Grade 3/4)

16

47

7

41

0.691

 Pulmonary dysfunction (Grade 3/4)

3

9

1

6

1.00

Cumulative toxicity risk score (Seattle criteria)

     

 Low risk (0 – 4)

22

65

13

76

0.448

 Intermediate risk (5 – 8)

5

15

3

18

 High risk (≥ 9)

7

20

1

6

Length of hospital stay (days)*‡

20.5 (12 – 80)

25 (15 – 31)

0.414

100 days TRM

     

 Yes (died)

6

18

2

12

0.703

 No (Alive)

28

82

15

88

  1. * median values with range.
  2. † mean number of antibiotics used per patient if a given antibiotic was used intravenously for more than 48 hours.
  3. ‡ from day of infusion of stem cell graft to day of hospital discharge.