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Table 2 Recovery of viable E6/E7 mRNA according to key clinical features of the women and cyto-histological characteristics of the samples

From: Retrieval of HPV oncogenes E6 and E7 mRNA from cervical specimens using a manual open technology protocol

 

mRNA E6 or E7

 

Characteristic

neg

(%)

pos

(%)

OR

(95% CI)

p

Age

<30

14

(58.3)

16

(44.4)

4.18

(0.87 to 20.05)

0.073

>30

10

(41.7)

20

(55.6)

1.0

 

First intercourse

<16

14

(58.3)

19

(52.8)

0.73

(0.2 to 2.72)

0.637

>16

10

(41.7)

17

(47.2)

1.0

 

Lifetime sex partners

>2

5

(20.8)

9

(25)

0.55

(0.11 to 2.69)

0.461

1-2

19

(79.2)

27

(75)

1.0

 

Current smoker

Yes

8

(33.3)

11

(30.6)

0.8

(0.2 to 3.18)

0.751

No

16

(66.7)

25

(69.4)

1.0

 

Cytology

ASC-H or HSIL

19

(79.2)

27

(75)

0.36

(0.06 to 2.02)

0.245

ASC-US or LSIL

5

(20.8)

9

(25)

1.0

 

Histology

CIN2-CIN3

21

(87.5)

35

(97.2)

5.43

(0.24 to 124.79)

0.290

Cervivitis-CIN1

3

(12.5)

1

(2.8)

1.0

 

HPV Type-specific mRNA transcription* **

DNA-HPV 16

Positive

17

(40.4)

25

(59.6)

9.08

(1.26 to 65.32)

0.028

DNA HPV 18

Positive

2

(28.5)

5

(71.5)

18.27

(1.86 to 392.44)

0.033

DNA HPV 31

Positive

14

(54.4)

12

(45.6)

3.18

(0.68 to 14.89)

0.142

DNA HPV 45

Positive

5

(50.0)

5

(50.0)

13.45

(0.73 to 246.64)

0.080

  1. *As per study design samples negative for a given HPV type were not re-tested for that type-specific mRNA; **percentages in rows.