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Table 2 Lymph-node status of the 175 study participants in relation to levels of PIK3CA-, PTEN mRNA expression and PIK3CA mutations in the primary breast carcinoma

From: Expression of PIK3CA, PTEN mRNA and PIK3CA mutations in primary breast cancer: association with lymph node metastases

 

PIK3CA expression

PTEN expression

PIK3CA mutations

 

Low PIK3CA

High PIK3CA

Low PTEN

High PTEN

Wildtype

Mutations

Number, N (%)

87 (50)

88 (50)

87 (50)

88 (50)

107 (61)

68 (39)

Lymph node status, N (%)

      

 No metastases

36 (41)

34 (39)

38 (44)

32 (36)

42 (39)

28 (41)

 Metastases

51 (59)

54 (61)

49 (56)

56 (64)

65 (61)

40 (59)

 

p = 0.71

p = 0.32

p = 0.80

  1. Low PIK3CA expression is PIK3CA expression ≤ 50.60 (median). Low PTEN expression is PTEN expression ≤ 22.98 (median).
  2. Wildtype = no PIK3CA mutations. HER2 human epidermal growth factor receptor 2.