Table 1 Clinical pathological characteristics of the 175 study participants in relation to levels of PIK3CA-, PTEN mRNA expression and PIK3CA mutations in the primary breast carcinoma
PIK3CA expression (n = 175) | PTEN expression (n = 175) | PIK3CA mutations (n = 175) | ||||
|---|---|---|---|---|---|---|
Low PIK3CA | High PIK3CA | Low PTEN | High PTEN | Wildtype | Mutations | |
Number, N (%) | 87 (50) | 88 (50) | 87 (50) | 88 (50) | 107 (61) | 68 (39) |
Age, years median (range) | 64 (38–85) | 65 (32–83) | 64 (36–85) | 63 (32–82) | 64 (32–85) | 63 (38–83) |
Tumour size, mm, median (range) | 21 (6–60) | 18 (6–51) | 21 (6–60) | 18 (6–50) | 19 (6–55) | 19 (7–60) |
Oestrogen receptor status, N (%) | ||||||
Positive | 74 (85) | 79 (90) | 74 (85) | 79 (90) | 92 (86) | 61 (90) |
Negative | 13 (15) | 9 (10) | 13 (15) | 9 (10) | 15 (14) | 7 (10) |
HER2 status, N (%) | ||||||
Normal expression | 65 (74) | 69 (78) | 59 (68) | 75 (85) | 81 (76) | 53 (78) |
Overexpression | 10 (11) | 11 (13) | 11 (13) | 10 (11) | 13 (12) | 8 (12) |
Unknown | 12 (14) | 8 (9) | 17 (19) | 3 (3) | 13 (12) | 7 (10) |
Histology, N (%) | ||||||
Invasive ductal carcinoma | 68 (78) | 70 (80) | 71 (82) | 67 (76) | 88 (82) | 50 (74) |
Invasive lobular carcinoma | 10 (11) | 15 (17) | 8 (9) | 17 (19) | 14 (13) | 11 (16) |
Other | 9 (10) | 3 (3) | 8 (9) | 4 (5) | 5 (5) | 7 (10) |