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Figure 2 | SpringerPlus

Figure 2

From: Polymorphisms in migraine-associated gene, atp1a2, and ischemic stroke risk in a biracial population: the genetics of early onset stroke study

Figure 2

Image demonstrating potential mechanisms relating how altered Na+/K+ATPase (as coded byATP1A2)function could be related to stroke risk. Decreased Na+/K+ ATPase activity leads to: altered ionic (Na+, K+) gradients resulting in excess intracellular Ca2+ (Danbolt 2001); impaired K+ channel-mediated membrane repolarization (Luo et al. 2004; Matsuda et al. 2001), and; elevated glutamate concentrations at the synaptic cleft (Rose et al. 2009). Elevated homocysteine has been shown to decrease Na+/K+ ATPase function (Machado et al. 2011; Streck et al. 2002).

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