Genotype | Events/N total | Unadjusted | Full Modela | Events/N total | Radiotherapy+Chemotherapy only | |||
---|---|---|---|---|---|---|---|---|
HR | 95% CI | HR | 95% CI | HR | 95% CI | |||
Breast cancer Mortality | ||||||||
GSTM1 | ||||||||
Positive genotype | 17/253 | 1.00 | Ref. | 1.00 | Ref. | 14/194 | 1.00 | Ref. |
Null genotype | 28/280 | 1.48 | 0.81-2.71 | 0.93 | 0.49-1.79 | 21/213 | 0.88 | 0.41-1.86 |
P b | 0.21 | 0.83 | 0.74 | |||||
GSTT1 | ||||||||
Positive genotype | 11/109 | 1.00 | Ref. | 1.00 | Ref. | 8/86 | 1.00 | Ref. |
Null genotype | 34/424 | 0.80 | 0.40-1.60 | 0.86 | 0.43-1.72 | 27/321 | 0.91 | 0.40-2.03 |
P b | 0.54 | 0.68 | 0.80 | |||||
GSTP1 | ||||||||
Ile/Ile | 16/233 | 1.00 | Ref. | 1.00 | Ref. | 14/176 | 1.00 | Ref. |
Ile/Val | 26/250 | 1.53 | 0.82-2.86 | 1.66 | 0.87-3.16 | 19/185 | 1.37 | 0.67-2.84 |
Val/Val | 3/60 | 0.75 | 0.22-2.58 | 0.63 | 0.17-2.27 | 2/46 | 0.42 | 0.10-2.12 |
P b | 0.71 | 0.82 | 0.74 | |||||
GSTP1 | ||||||||
Ile/Ile | 16/223 | 1.00 | Ref. | 1.00 | Ref. | 14/176 | 1.00 | Ref. |
Val/Val + Val/Ile | 29/310 | 1.38 | 0.74-2.55 | 1.43 | 0.76-2.68 | 21/321 | 1.17 | 0.58-2.37 |
P b | 0.30 | 0.27 | 0.67 | |||||
All cause Mortality | ||||||||
GSTM1 | ||||||||
Positive genotype | 45/208 | 1.00 | Ref. | 1.00 | Ref. | 31/194 | 1.00 | Ref. |
Null genotype | 54/226 | 1.07 | 0.71-1.58 | 0.88 | 0.57-1.34 | 38/213 | 0.77 | 0.45-1.30 |
P b | 0.76 | 0.55 | 0.32 | |||||
GSTT1 | ||||||||
Positive genotype | 17/109 | 1.00 | Ref. | 1.00 | Ref. | 12/86 | 1.00 | Ref. |
Null genotype | 82/424 | 1.21 | 0.71-2.03 | 1.22 | 0.72-2.08 | 57/321 | 1.33 | 0.71-2.51 |
P b | 0.48 | 0.47 | 0.38 | |||||
GSTP1 | ||||||||
Ile/Ile | 30/223 | 1.00 | Ref. | 1.00 | Ref. | 24/176 | 1.00 | Ref. |
Ile/Val | 59/250 | 1.89 | 1.21-2.95 | 1.98 | 1.25-3.12 | 39/185 | 1.72 | 1.01-2.93 |
Val/Val | 10/60 | 1.41 | 0.68-2.89 | 1.24 | 0.59-2.58 | 6/46 | 0.60 | 0.20-1.75 |
P b | 0.05 | 0.08 | 0.72 | |||||
GSTP1 | ||||||||
Ile/Ile | 30/223 | 1.00 | Ref. | 1.00 | Ref. | 24/176 | 1.00 | Ref. |
Ile/Val + Val/Val | 69/310 | 1.80 | 1.16-2.77 | 1.81 | 1.16-2.82 | 45/231 | 1.47 | 0.87-2.47 |
P b | 0.008 | 0.008 | 0.15 |