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Table 2 Associations between SNPs and participant characteristics

From: Associations between null mutations in GSTT1 and GSTM1, the GSTP1 Ile105Val polymorphism, and mortality in breast cancer survivors

All participants N=553

 

GSTM1

GSTT1

GSTP1

 

Positive

Null

Positive

Null

Ile/Ile

Ile/Val

Val/Val

BMI (kg/m 2 )

       

<=25

102

116

52

166

95

103

20

(40.3%)

(41.43%)

(47.7%)

(39.2%)

(42.6%)

(41.2%)

(33.3%)

>25

151

164

57

258

128

147

40

(59.7%)

(58.6%)

(52.2%)

(60.8%)

(57.4%)

(58.8)

(66.7%)

 

χ2=0.10 P =0.79

χ2=2.62 P =0.11

χ2=1.70 P =0.43

ER a

       

ER-

45

64

15

94

41

57

11

(19.6%)

(25.2%)

(14.7%)

(24.6%)

(19.8%)

(25.6%)

(20.0%)

ER+

185

190

87

288

166

165

44

(80.4%)

(74.8%)

(85.3%)

(75.4%)

(80.2%)

(74.3%)

(80.0%)

 

χ2=2.19 P=0.14

χ2=4.52 P=0.03

χ2=2.34 P=0.31

Stage

       

Local

192

191

75

308

154

188

41

(75.9%)

(68.2%)

(68.8%)

(72.6%)

(67.1%)

(75.2%)

(68.3%)

Regional

61

89

34

116

69

62

19

(24.1%)

(31.8%)

(31.2%)

(27.4%)

(30.9%)

(24.8%)

(31.7%)

 

χ2=3.87 P=0.05

χ2=0.63 P=0.42

χ2=2.61 P=0.27

Omitting patients who received surgery only N=407

 

GSTM1

GSTT1

GSTP1

 

Positive

Null

Positive

Null

Ile/Ile

Ile/Val

Val/Val

BMI (kg/m 2 )

       

<=25

72

89

40

121

72

73

16

(37.1%)

(41.8%)

(46.5%)

(37.7%)

(40.9%)

(39.5%)

(34.8%)

>25

122

124

46

200

104

112

30

(62.9%)

(58.2%)

(53.5%)

(62.3%)

(59.1%)

(60.5)

(65.2%)

 

χ2=0.92 P =0.34

χ2=2.21 P =0.14

χ2=0.57 P =0.75

ER a

       

ER-

38

57

13

82

36

50

9

(20.5%)

(28.6%)

(15.3%)

(27.4%)

(21.4%)

(29.1%)

(20.5%)

ER+

147

142

72

217

132

122

35

(79.5%)

(71.4%)

(84.7%)

(72.6%)

(78.6%)

(70.9%)

(79.6%)

 

χ2=3.38 P=0.06

χ2=5.23 P=0.02

χ2=3.16 P=0.21

Stage

       

Local

141

136

59

218

113

134

30

(72.7%)

(63.9%)

(68.6%)

(67.9%)

(64.2%)

(72.4%)

(65.2%)

Regional

53

77

27

103

63

51

16

(27.3%)

(36.1%)

(31.4%)

(32.1%)

(35.8%)

(27.68%)

(34.8%)

 

χ2=3.64 P=0.06

χ2=0.01 P=0.91

χ2=3.00 P=0.22

  1. a Omitted 49 participants with unknown ER status’.