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Figure 5

From: Contribution of extrahepatic small cells resembling small hepatocyte-like progenitor cells to liver mass maintenance in transplantation model of retrorsine-pretreated liver

Figure 5

Expression of CYP1A2 in retrorsine pretreated liver eight weeks after transplantation. (Left column) CYP1A2. (Middle column) GFP. (Right column) Merged image of CYP1A2, GFP and nucleus (blue). (A)-(C) Nodule of SHPCs (upper side of the picture) is expansively growing and compressing surrounding hepatocytes which have CYP1A2 expression. (D)-(F) Large hepatocyte-like cells (megalocyte) are weekly positive for CYP1A2. (G)-(I) Majority of the GFP positive SHPCs-like cells lack in CYP1A2 expression. Some of them express CYP1A2 weekly. (J)-(L) Small cluster of GFP positive small cells are surrounded by CYP1A2 positive larger cells. Nodule of SHPCs is also observed (lower part of the picture). (M)-(O) 14 days after hepatocyte transplantation in retrorsine-pretreated hepatectomized liver. Formation of nodules by transplanted hepatocytes (GFP positive) and endogeneous SHPCs (GFP negative) are observed. Majorities of transplanted hepatocytes are CYP1A2 positive, opposite of GFP positive SHPCs-like cells.

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