Table 3 The distribution (%) of high-risk patients among the different SNP genotypes (R462Q and D541E) of the RNASEL gene, X 2 statistical p-values
SNP | Genotype | T stage | PSA | Gleason score > 7% (n) | P-value1 | P-values2 | OR (95% CI) | ||
|---|---|---|---|---|---|---|---|---|---|
Stage 3% (n) | Stage 4% (n) | > 20 ng/ml% (n) | > 1000 ng/ml% (n) | ||||||
R462Q-rs486907 | AA | 47.2 (17) | 33.3 (12) | 45.4 (15) | 3.03 (1) | 33.3 (12) | ≤ 0.001 | 0.003 | 0.161 (0.048-0.543) |
GA | 13.8 (16) | 8.6 (10) | 14.6 (16) | 0.9 (1) | 8.3 (10) | 0.271 | 1.511 (0.724-3.153) | ||
GG | 21.3 (16) | 2.7 (2) | 15.9 (11) | 0.0 (0) | 6.8 (5) | - | - | ||
D541E-rs627928 | GG | 35.1 (26) | 20.3 (15) | 29.0 (20) | 2.9 (2) | 21.6 (16) | ≤ 0.001 | 0.017 | 0.205 (0.056-0.755) |
TG | 16.7 (20) | 7.5 (9) | 16.5 (18) | 0.0 (0) | 9.4 (11) | 0.081 | 0.340 (0.101-1.142) | ||
TT | 9.1 (3) | 0.0 | 12.1 (4) | 0.0 (0) | 0.0 (0) | - | - | ||