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Table 4 HLA-C single amino acid polymorphisms

From: Lack of HLA predominance and HLA shared epitopes in biliary Atresia

Position**

Amino acid

BA (177) n(%)

Controls (350) n(%)

Odds Ratio

Pu value#

Pc value#

9

S

43(24.3)

109(31.1)

0.78

0.12

NS

9

D

106(59.9)

190(54.3)

1.10

0.17

NS

9

Y

125(70.6)

236(67.4)

1.05

0.35

NS

11

S

56(31.6)

132(37.7)

0.84

0.20

NS

14

W

39(22.0)

98(28.0)

0.79

0.16

NS

21

H

61(34.5)

117(33.4)

1.03

0.74

NS

24

S

116(65.5)

208(59.4)

1.10

0.13

NS

24

A

149(84.2)

290(82.9)

1.02

0.50

NS

35

Q

49(27.7)

92(26.3)

1.05

0.68

NS

49

E

39(22.0)

98(28.0)

0.79

0.16

NS

66

N

48(27.1)

96(27.4)

0.99

1.00

NS

73

T

113(63.8)

230(65.7)

0.97

0.80

NS

73

A

136(76.8)

277(79.1)

0.97

0.71

NS

77

N

106(59.9)

227(64.9)

0.92

0.34

NS

77

S

153(86.4)

294(84.0)

1.03

0.30

NS

80

K

106(59.9)

227(64.9)

0.92

0.34

NS

80

N

153(86.4)

294(84.0)

1.03

0.30

NS

90

D

125(70.6)

255(72.9)

0.97

0.73

NS

90

A

129(72.9)

257(73.4)

0.99

0.94

NS

91

R

20(11.3)

31(8.9)

1.28

0.35

NS

  1. # Pu, uncorrected P values; Pc, corrected P values.
  2. **Polymorphic amino acid positions analyzed: 6, 9, 11, 14, 16, 21, 24, 35, 45, 49, 52, 63, 66, 69, 73, 76, 77, 80, 90, 91, 94, 95, 97, 99, 103, 113, 114, 116, 138, 143, 147, 152, 156, 163, 170, 173, 175, 177, 178, 180.
  3. Not shown are amino acid residues that were present in 90% or greater in both patient and control groups, or were present in 10% or fewer in both patient and control groups.