Figure 4

Production of IFN-α and IFN-β in CVS- and ERA-inoculated JAWS II cells. (A) The levels of IFN-α (white) and IFN-β (black) in the culture supernatant 48 h after infection in CVS- or ERA-infected JAWS II cells at various MOIs (0.5, 5, and 10). (B) Serial changes in IFN-α (dotted line) and IFN-β (black line) production in the CVS-infected (squares) and ERA-infected JAWS II cells (circles) at an MOI of 10. The levels of type I IFN were quantified by ELISA 72 h after infection. The experiments were performed three times and error bars represent SEM. *p < 0.001, **p < 0.01.