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Table 4 Cox proportional hazard relating coexistence of a) AD-HS, b) AD, and c) HS to overall survival compared to BC patients without these comorbidities

From: Autoimmune diseases and hypersensitivities improve the prognosis in ER-negative breast cancer

a) BC patients with coexisting AD or HS
  All patients. N=1508, N=1363 and N=1363.      
   HR 95% CI for HR p-value      
AD-HS, adjusted for: N   Lower Upper       
Age at diagnosis 194 0.88 0.71 1.10 0.25      
Age at diagnosis, TNM-stage 185 0.91 0.72 1.14 0.409      
Age at diagnosis, TNM-stage, Screening 185 0.94 0.75 1.18 0.579      
  Patients younger than 65 years at diagnosis of BC. N=1021 Patients younger than 50 years at diagnosis of BC. N=473
  N HR 95% CI for HR p-value N HR 95% CI for HR p-value
AD-HS, adjusted for:    Lower Upper     Lower Upper  
Age at diagnosis, TNM-stage 130 0.94 0.75 1.18 0.579 56 0.74 0.48 1.16 0.186
b) BC patients with coexisting AD       
  All patients. N=1580 and N=1433      
  N HR 95% CI for HR p-value      
AD adjusted for:    Lower Upper       
Age at diagnosis 122 0.90 0.48 1.16 0.460      
Age at diagnosis, TNM-stage 115 0.90 0.69 1.20 0.480      
  Patients younger than 65 years at diagnosis of BC. N=1071 Patients younger than 50 years at diagnosis of BC. N=500
  N HR 95% CI for HR p-value N HR 95% CI for HR p-value
AD adjusted for:    Lower Upper     Lower Upper  
Age at diagnosis, TNM-stage 80 0.95 0.66 1.36 0.773 29 0.81 0.45 1.45 0.472
c) BC patients with coexisting HS       
  All patients included. N= 1632 and N=1363      
  N HR 95% CI for HR p-value      
HS adjusted for:    Lower Upper       
Age at diagnosis 72 0.85 0.60 1.23 0.388      
Age at diagnosis, TNM-stage 70 0.93 0.64 1.34 0.691      
  Patients younger than 65 years at diagnosis of BC. N=1101 Patients younger than 50 years at diagnosis of BC. N=502
  N HR 95% CI for HR p-value N HR 95% CI for HR p-value
HS adjusted for:    Lower Upper     Lower Upper  
Age at diagnosis, TNM-stage 50 0.86 0.54 1.37 0.524 27 0.69 0.36 1.33 0.269
  1. The HR shown is for a) AD-HS combined, b) AD, or c) HS adjusted for the variables in the left column.
  2. All analyses were performed using all patients, with an age cutoff at less than 65 years old, and an age cutoff at less than 50 years old for each group respectively.