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Table 4 Cox proportional hazard relating coexistence of a) AD-HS, b) AD, and c) HS to overall survival compared to BC patients without these comorbidities

From: Autoimmune diseases and hypersensitivities improve the prognosis in ER-negative breast cancer

a) BC patients with coexisting AD or HS

 

All patients. N=1508, N=1363 and N=1363.

     
  

HR

95% CI for HR

p-value

     

AD-HS, adjusted for:

N

 

Lower

Upper

      

Age at diagnosis

194

0.88

0.71

1.10

0.25

     

Age at diagnosis, TNM-stage

185

0.91

0.72

1.14

0.409

     

Age at diagnosis, TNM-stage, Screening

185

0.94

0.75

1.18

0.579

     
 

Patients younger than 65 years at diagnosis of BC. N=1021

Patients younger than 50 years at diagnosis of BC. N=473

 

N

HR

95% CI for HR

p-value

N

HR

95% CI for HR

p-value

AD-HS, adjusted for:

  

Lower

Upper

   

Lower

Upper

 

Age at diagnosis, TNM-stage

130

0.94

0.75

1.18

0.579

56

0.74

0.48

1.16

0.186

b) BC patients with coexisting AD

      
 

All patients. N=1580 and N=1433

     
 

N

HR

95% CI for HR

p-value

     

AD adjusted for:

  

Lower

Upper

      

Age at diagnosis

122

0.90

0.48

1.16

0.460

     

Age at diagnosis, TNM-stage

115

0.90

0.69

1.20

0.480

     
 

Patients younger than 65 years at diagnosis of BC. N=1071

Patients younger than 50 years at diagnosis of BC. N=500

 

N

HR

95% CI for HR

p-value

N

HR

95% CI for HR

p-value

AD adjusted for:

  

Lower

Upper

   

Lower

Upper

 

Age at diagnosis, TNM-stage

80

0.95

0.66

1.36

0.773

29

0.81

0.45

1.45

0.472

c) BC patients with coexisting HS

      
 

All patients included. N= 1632 and N=1363

     
 

N

HR

95% CI for HR

p-value

     

HS adjusted for:

  

Lower

Upper

      

Age at diagnosis

72

0.85

0.60

1.23

0.388

     

Age at diagnosis, TNM-stage

70

0.93

0.64

1.34

0.691

     
 

Patients younger than 65 years at diagnosis of BC. N=1101

Patients younger than 50 years at diagnosis of BC. N=502

 

N

HR

95% CI for HR

p-value

N

HR

95% CI for HR

p-value

HS adjusted for:

  

Lower

Upper

   

Lower

Upper

 

Age at diagnosis, TNM-stage

50

0.86

0.54

1.37

0.524

27

0.69

0.36

1.33

0.269

  1. The HR shown is for a) AD-HS combined, b) AD, or c) HS adjusted for the variables in the left column.
  2. All analyses were performed using all patients, with an age cutoff at less than 65 years old, and an age cutoff at less than 50 years old for each group respectively.