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Table 3 Association of HLA, CTLA, FAS, and TNF loci with severe fibrosis and normalisation of ALT in type 1 AIH patients

From: Association of the HLA locus and TNF with type I autoimmune hepatitis susceptibility in New Zealand Caucasians

SNP    Genotype    MAF Unadjusted±P value (allele) OR (allele) [95% CI]
rs2187668 (HLA-DRB1*03:01)    AA AG GG A
  Fibrosis ≥ Metavir 3 Yes 4(0.089) 16(0.356) 25(0.556) 24(0.267) 0.46 0.76 [0.38-1.55]
  (at diagnosis) No 5(0.161) 10(0.323) 16(0.516) 20(0.323)   
  Incomplete normalization of ALT Yes 1(0.067) 6(0.400) 8(0.533) 8(0.267) 0.67 0.82 [0.34-2.01]
  (at 6 months post diagnosis) No 9(0.145) 20(0.323) 33(0.532) 38(0.306)   
rs660895 (HLA-DRB1*04:01)    AA AG GG G   
  Fibrosis ≥ Metavir 3 Yes 27(0.600) 15(0.333) 3(0.067) 21(0.233) 0.22 1.56 [0.76-3.22]
  (at diagnosis) No 13(0.419) 16(0.516) 2(0.065) 20(0.323)   
  Incomplete normalization of ALT Yes 9(0.600) 4(0.267) 2(0.133) 8(0.267) 0.96 1.00 [0.40-2.46]
  (at 6 months post diagnosis) No 32(0.516) 27(0.435) 3(0.048) 33(0.266)   
rs3749971 (HLA-A1-B8-DR3)    AA AG GG A   
  Fibrosis ≥ Metavir 3 Yes 3(0.067) 13(0.289) 29(0.644) 19(0.211) 0.26 1.24 [0.54-2.83]
  (at diagnosis) No 1(0.032) 9(0.290) 21(0.677) 11(0.177)   
  Incomplete normalization of ALT Yes 0(0.000) 6(0.400) 9(0.600) 6(0.200) 0.98 0.99[0.37-2.68]
  (at 6 months post diagnosis) No 4(0.065) 17(0.274) 41(0.661) 25(0.202)   
rs231775 (CTLA4)    AA AG GG G   
  Fibrosis ≥ Metavir 3 Yes 20(0.444) 15(0.333) 10(0.222) 35(0.389) 0.29 0.69 [0.35-1.38]
  (at diagnosis) No 13(0.419) 17(0.548) 1(0.032) 19(0.306)   
  Incomplete normalization of ALT Yes 7(0.467) 6(0.400) 2(0.133) 10(0.333) 0.70 1.18 [0.51-2.74]
  (at 6 months post diagnosis) No 26(0.419) 26(0.419) 10(0.161) 46(0.371)   
rs1800629 (TNF)    AA AG GG A   
  Fibrosis ≥ Metavir 3 Yes 5(0.111) 19(0.422) 21(0.467) 29(0.322) 0.68 1.16 [0.57-2.35]
  (at diagnosis) No 4(0.129) 10(0.323) 17(0.548) 18(0.290)   
  Incomplete normalization of ALT Yes 1(0.067) 7(0.467) 7(0.467) 9(0.300) 0.81 0.90 [0.38-2.14]
  (at 6 months post diagnosis) No 9(0.145) 22(0.355) 31(0.500) 40(0.323)   
rs1800682 (FAS)    CC CT TT C   
  Fibrosis ≥ Metavir 3 Yes 14(0.311) 21(0.467) 10(0.222) 49(0.544) 0.035 2.03 [1.05-3.93]
  (at diagnosis) No 5(0.161) 13(0.419) 13(0.419) 23(0.371)   
  Incomplete normalization of ALT Yes 9(0.600) 4(0.267) 2(0.133) 22(0.733) 0.0015± 3.94 [1.62-9.54]
  (at 6 months post diagnosis) No 10(0.161) 31(0.500) 21(0.339) 51(0.411)   
  1. ±Significant after Bonferroni correction (0.05/12 tests, p < 0.004).