Table 2 Allele and genotype frequencies of HLA, CTLA4, FAS and TNF SNPs in New Zealand Caucasian controls and patients with type 1 AIH
SNP | Phenotype | Genotype frequency | Minor allele frequency | Unadjusted P (allele) | Odd ratio (allele) [95% CI] | ||
|---|---|---|---|---|---|---|---|
rs2187668 (HLA-DRB1*03:01) | Â | AA | AG | GG | A | Â | Â |
AIH | 10(0.130) | 26(0.338) | 41(0.532) | 46(0.299) | <0.0001± | 2.45 [1.65-3.61] | |
Controls | 13(0.029) | 109(0.240) | 333(0.732) | 135(0.148) | Â | Â | |
rs660895 (HLA-DRB1*04:01) | Â | AA | AG | GG | G | Â | Â |
AIH | 41(0.532) | 31(0.403) | 5(0.065) | 41(0.266) | 0.10 | 0.72 [0.49-1.07] | |
Controls | 288(0.633) | 145(0.319) | 22(0.048) | 189(0.208) | Â | Â | |
rs3749971 (HLA-A1-B8-DR3) | Â | AA | AG | GG | A | Â | Â |
AIH | 4(0.052) | 23(0.299) | 50(0.649) | 31(0.201) | 0.004± | 1.89 [1.21-2.94] | |
Controls | 4(0.009) | 98(0.218) | 348(0.773) | 106(0.118) | Â | Â | |
rs231775 (CTLA4) | Â | AA | AG | GG | G | Â | Â |
AIH | 33(0.429) | 32(0.416) | 12(0.156) | 56(0.364) | 0.42 | 1.16 [0.81-1.65] | |
Controls | 168(0.369) | 212(0.466) | 75(0.165) | 362(0.398) | Â | Â | |
rs1800629 (TNF) | Â | AA | AG | GG | A | Â | Â |
AIH | 10(0.130) | 29(0.377) | 38(0.494) | 49(0.318) | 0.0001± | 2.06 [1.41-3.01] | |
Controls | 20(0.044) | 128(0.281) | 307(0.675) | 168(0.185) | Â | Â | |
rs1800682 (FAS) | Â | CC | CT | TT | C | Â | Â |
AIH | 19(0.247) | 35(0.455) | 23(0.299) | 73(0.474) | 0.93 | 1.01 [0.72-1.43] | |
| Â | Controls | 107(0.235) | 214(0.470) | 134(0.295) | 428(0.470) | Â | Â |