|
SNP
|
Phenotype
|
Genotype frequency
|
Minor allele frequency
|
Unadjusted P (allele)
|
Odd ratio (allele) [95% CI]
|
|---|
|
rs2187668 (HLA-DRB1*03:01)
| |
AA
|
AG
|
GG
|
A
| | |
|
AIH
|
10(0.130)
|
26(0.338)
|
41(0.532)
|
46(0.299)
|
<0.0001±
|
2.45 [1.65-3.61]
|
|
Controls
|
13(0.029)
|
109(0.240)
|
333(0.732)
|
135(0.148)
| | |
|
rs660895 (HLA-DRB1*04:01)
| |
AA
|
AG
|
GG
|
G
| | |
|
AIH
|
41(0.532)
|
31(0.403)
|
5(0.065)
|
41(0.266)
|
0.10
|
0.72 [0.49-1.07]
|
|
Controls
|
288(0.633)
|
145(0.319)
|
22(0.048)
|
189(0.208)
| | |
|
rs3749971 (HLA-A1-B8-DR3)
| |
AA
|
AG
|
GG
|
A
| | |
|
AIH
|
4(0.052)
|
23(0.299)
|
50(0.649)
|
31(0.201)
|
0.004±
|
1.89 [1.21-2.94]
|
|
Controls
|
4(0.009)
|
98(0.218)
|
348(0.773)
|
106(0.118)
| | |
|
rs231775 (CTLA4)
| |
AA
|
AG
|
GG
|
G
| | |
|
AIH
|
33(0.429)
|
32(0.416)
|
12(0.156)
|
56(0.364)
|
0.42
|
1.16 [0.81-1.65]
|
|
Controls
|
168(0.369)
|
212(0.466)
|
75(0.165)
|
362(0.398)
| | |
|
rs1800629 (TNF)
| |
AA
|
AG
|
GG
|
A
| | |
|
AIH
|
10(0.130)
|
29(0.377)
|
38(0.494)
|
49(0.318)
|
0.0001±
|
2.06 [1.41-3.01]
|
|
Controls
|
20(0.044)
|
128(0.281)
|
307(0.675)
|
168(0.185)
| | |
|
rs1800682 (FAS)
| |
CC
|
CT
|
TT
|
C
| | |
|
AIH
|
19(0.247)
|
35(0.455)
|
23(0.299)
|
73(0.474)
|
0.93
|
1.01 [0.72-1.43]
|
| |
Controls
|
107(0.235)
|
214(0.470)
|
134(0.295)
|
428(0.470)
| | |
-
±Significant at α=0.05 after Bonferroni correction (0.05/6 tests, p < 0.008).
