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Table 2 Allele and genotype frequencies of HLA, CTLA4, FAS and TNF SNPs in New Zealand Caucasian controls and patients with type 1 AIH

From: Association of the HLA locus and TNF with type I autoimmune hepatitis susceptibility in New Zealand Caucasians

SNP Phenotype Genotype frequency Minor allele frequency Unadjusted P (allele) Odd ratio (allele) [95% CI]
rs2187668 (HLA-DRB1*03:01)   AA AG GG A   
AIH 10(0.130) 26(0.338) 41(0.532) 46(0.299) <0.0001± 2.45 [1.65-3.61]
Controls 13(0.029) 109(0.240) 333(0.732) 135(0.148)   
rs660895 (HLA-DRB1*04:01)   AA AG GG G   
AIH 41(0.532) 31(0.403) 5(0.065) 41(0.266) 0.10 0.72 [0.49-1.07]
Controls 288(0.633) 145(0.319) 22(0.048) 189(0.208)   
rs3749971 (HLA-A1-B8-DR3)   AA AG GG A   
AIH 4(0.052) 23(0.299) 50(0.649) 31(0.201) 0.004± 1.89 [1.21-2.94]
Controls 4(0.009) 98(0.218) 348(0.773) 106(0.118)   
rs231775 (CTLA4)   AA AG GG G   
AIH 33(0.429) 32(0.416) 12(0.156) 56(0.364) 0.42 1.16 [0.81-1.65]
Controls 168(0.369) 212(0.466) 75(0.165) 362(0.398)   
rs1800629 (TNF)   AA AG GG A   
AIH 10(0.130) 29(0.377) 38(0.494) 49(0.318) 0.0001± 2.06 [1.41-3.01]
Controls 20(0.044) 128(0.281) 307(0.675) 168(0.185)   
rs1800682 (FAS)   CC CT TT C   
AIH 19(0.247) 35(0.455) 23(0.299) 73(0.474) 0.93 1.01 [0.72-1.43]
  Controls 107(0.235) 214(0.470) 134(0.295) 428(0.470)   
  1. ±Significant at α=0.05 after Bonferroni correction (0.05/6 tests, p < 0.008).