Table 2 Plasma concentrations (μg/ml) of vancomycin or BT2-peg2-vancomycin (BTV) in the osteomyelitis animals following 21 days of treatment
n | Plasma concentration (μg/ml) | Time (h) after last dose | ||
|---|---|---|---|---|
Median | Range | |||
Vancomycin HCl twice daily | 16 | 0.71 | 0.24-2.00 | 12 |
BTV twice daily | 13 | 129.98 | 74.56-207.90 | 12 |
BTV twice daily for 3.5 days and then every four days | 14 | 0.88 | 0.00-4.14 | 48 |
BTV once per week | 15 | 0.00 | 0.00-0.34 | 168 |