Table 1 Kidney weights, creatinine, BUN and albumin (range) values after treatment with vancomycin HCl or BT2-peg2-vancomycin diformate (BTV)
Group | Kidney weight (grams) | Creatinine (mg/dl) | BUN (mg/dl) | Albumin (g/dl) |
|---|---|---|---|---|
No treatment | 1.4 (1.2-1.9) | 0.5 (0.5-0.6) | 20 (17–25) | 3.6 (3.3-3.9) |
Vancomycin HCl twice daily | 1.4 (1.1-1.7) | 0.5 (0.4-0.6) | 18.5 (15–21) | 3.4 (3.1-3.6) |
BTV twice daily | 4.1 (2.4-6.0) | 1.5 (1.2-2.2) | 76.5 (56–114) | 2.8 (2.6-3.0) |
BTV twice daily for 3.5 days and then every four days | 1.7 (1.3-2.2) | 0.6 (0.5-1.2) | 31 (22–47) | 3.6 (3.1-4) |
BTV once per week | 1.5 (1.4-1.8) | 0.5 (0.4-0.6) | 19 (17–21) | 3.6 (3.3-3.8) |