From: Computational modeling of the p7 monomer from HCV and its interaction with small molecule drugs
 | Kink [°] | Tilt [°] |
---|---|---|
Individual TMDs | Â | Â |
TMD110-32 | 156.2 ± 9.4 | 14.1 ± 5.5 |
TMD236-58 | 142.6 ± 7.3 | 8.9 ± 4.2 |
TMD11-32 | 147.5 ± 9.1 | 20.1 ± 4.2 |
TMD2-F44Y | 136.1 ± 21.0 | 20.8 ± 4.9 |
TMD2-Y42/45S | 162.0 ± 8.1 | 8.5 ± 3.5 |
TMD2-Y42/45F | 153.0 ± 11.3 | 7.8 ± 3.9 |
Monomer | Â | Â |
M NL | Â | Â |
TMD1 | 161.7 ± 5.6 | 24.4 ± 6.9 |
TMD2 | 143.1 ± 8.4 | 28.8 ± 11.8 |
M L | Â | Â |
TMD1 | 159.2 ± 4.3 | 12.8 ± 4.3 |
TMD2 | 159.6 ± 5.7 | 18.6 ± 2.9 |