Skip to main content

Table 1 Averaged kink and tilt angles in degree of the individual TMDs and the TMDs of the monomer

From: Computational modeling of the p7 monomer from HCV and its interaction with small molecule drugs

 

Kink [°]

Tilt [°]

Individual TMDs

  

TMD110-32

156.2 ± 9.4

14.1 ± 5.5

TMD236-58

142.6 ± 7.3

8.9 ± 4.2

TMD11-32

147.5 ± 9.1

20.1 ± 4.2

TMD2-F44Y

136.1 ± 21.0

20.8 ± 4.9

TMD2-Y42/45S

162.0 ± 8.1

8.5 ± 3.5

TMD2-Y42/45F

153.0 ± 11.3

7.8 ± 3.9

Monomer

  

M NL

  

TMD1

161.7 ± 5.6

24.4 ± 6.9

TMD2

143.1 ± 8.4

28.8 ± 11.8

M L

  

TMD1

159.2 ± 4.3

12.8 ± 4.3

TMD2

159.6 ± 5.7

18.6 ± 2.9

  1. The values represent averages taken over the entire length of each of the simulations.