|
Parameters
|
Number of patients/ recurrence/death
|
Disease-free survival
|
Overall survival
|
|---|
|
Mean survival (95% CI) months
|
P-value
|
Mean survival(95% CI) months
|
P-value
|
|---|
|
Nuclear HIF-1α
| | |
0.911
| |
0.943
|
|
Negative
|
697/61/58
|
126 (122 − 130)
| |
129 (127 − 132)
| |
|
Positive
|
24/2/2
|
120 (108 − 133)
| |
131 (122 − 141)
| |
|
Cytoplasmic HIF-1α
| | |
N/A
| |
N/A
|
|
Negative
|
717/63
|
N/A
| |
N/A
| |
|
Positive
|
4/0
|
N/A
| |
N/A
| |
|
Tumoral SDHA
| | |
0.670
| |
0.085
|
|
Negative/Low
|
360/35/26
|
125 (121 − 129)
| |
131 (128 − 135)
| |
|
High
|
361/28/34
|
126 (120 − 132)
| |
126 (121 − 130)
| |
|
Stromal SDHA
| | |
0.853
| |
0.901
|
|
Negative
|
665/58/56
|
126 (123 − 130)
| |
130 (127 − 132)
| |
|
Positive
|
56/5/4
|
115 (101 − 130)
| |
121 (107 − 134)
| |
|
Tumoral SDHB
| | |
0.124
| |
0.715
|
|
Negative/Low
|
269/31/26
|
123 (119 − 128)
| |
129 (125 − 133)
| |
|
High
|
452/32/34
|
126 (121 − 131)
| |
129 (125 − 132)
| |
|
Stromal SDHB
| | |
0.821
| |
0.981
|
|
Negative
|
641/57/54
|
126 (122 − 130)
| |
130 (127 − 132)
| |
|
Positive
|
80/6/6
|
119 (110 − 128)
| |
123 (114 − 131)
| |
- SDH succinate dehydrogenase P-value by log-rank test.
