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Table 8 Univariate analysis of disease-free survival and overall survival according to breast-tumor expression of hypoxia-related proteins

From: Succinate dehydrogenase expression in breast cancer

Parameters Number of patients/ recurrence/death Disease-free survival Overall survival
Mean survival (95% CI) months P-value Mean survival(95% CI) months P-value
Nuclear HIF-1α    0.911   0.943
 Negative 697/61/58 126 (122 − 130)   129 (127 − 132)  
 Positive 24/2/2 120 (108 − 133)   131 (122 − 141)  
Cytoplasmic HIF-1α    N/A   N/A
 Negative 717/63 N/A   N/A  
 Positive 4/0 N/A   N/A  
Tumoral SDHA    0.670   0.085
 Negative/Low 360/35/26 125 (121 − 129)   131 (128 − 135)  
 High 361/28/34 126 (120 − 132)   126 (121 − 130)  
Stromal SDHA    0.853   0.901
 Negative 665/58/56 126 (123 − 130)   130 (127 − 132)  
 Positive 56/5/4 115 (101 − 130)   121 (107 − 134)  
Tumoral SDHB    0.124   0.715
 Negative/Low 269/31/26 123 (119 − 128)   129 (125 − 133)  
 High 452/32/34 126 (121 − 131)   129 (125 − 132)  
Stromal SDHB    0.821   0.981
 Negative 641/57/54 126 (122 − 130)   130 (127 − 132)  
 Positive 80/6/6 119 (110 − 128)   123 (114 − 131)  
  1. SDH succinate dehydrogenase P-value by log-rank test.