Table 8 Univariate analysis of disease-free survival and overall survival according to breast-tumor expression of hypoxia-related proteins
Parameters | Number of patients/ recurrence/death | Disease-free survival | Overall survival | ||
|---|---|---|---|---|---|
Mean survival (95% CI) months | P-value | Mean survival(95% CI) months | P-value | ||
Nuclear HIF-1α | 0.911 | 0.943 | |||
Negative | 697/61/58 | 126 (122 − 130) | 129 (127 − 132) | ||
Positive | 24/2/2 | 120 (108 − 133) | 131 (122 − 141) | ||
Cytoplasmic HIF-1α | N/A | N/A | |||
Negative | 717/63 | N/A | N/A | ||
Positive | 4/0 | N/A | N/A | ||
Tumoral SDHA | 0.670 | 0.085 | |||
Negative/Low | 360/35/26 | 125 (121 − 129) | 131 (128 − 135) | ||
High | 361/28/34 | 126 (120 − 132) | 126 (121 − 130) | ||
Stromal SDHA | 0.853 | 0.901 | |||
Negative | 665/58/56 | 126 (123 − 130) | 130 (127 − 132) | ||
Positive | 56/5/4 | 115 (101 − 130) | 121 (107 − 134) | ||
Tumoral SDHB | 0.124 | 0.715 | |||
Negative/Low | 269/31/26 | 123 (119 − 128) | 129 (125 − 133) | ||
High | 452/32/34 | 126 (121 − 131) | 129 (125 − 132) | ||
Stromal SDHB | 0.821 | 0.981 | |||
Negative | 641/57/54 | 126 (122 − 130) | 130 (127 − 132) | ||
Positive | 80/6/6 | 119 (110 − 128) | 123 (114 − 131) | ||