|
Factors
|
Tumor phenotype
|
Stroma phenotype
|
|---|
|
SDHA (+)/ SDHB
|
SDHA (+)/ SDHB
|
SDHA (−)/ SDHB
|
SDHA (-)/ SDHB
|
P
|
SDHA (+)/ SDHB
|
SDHA (+)/ SDHB
|
SDHA (−)/ SDHB
|
SDHA (−)/ SDHB
|
P
|
|---|
|
(+) n = 679 (%)
|
(−) n = 1 (%)
|
(+) n = 18 (%)
|
(−) n = 23 (%)
|
(+) n = 42 (%)
|
(−) n = 14 (%)
|
(+) n = 38 (%)
|
(−) n = 627 (%)
|
|---|
|
Histologic grade
| | | | |
0.038
| | | | |
0.150
|
|
I/II
|
450 (66.3)
|
1 (100.0)
|
13 (72.2)
|
20 (87.0)
| |
25 (59.5)
|
7 (50.0)
|
26 (68.4)
|
426 (67.9)
| |
|
III
|
229 (33.7)
|
0 (0.0)
|
5 (27.8)
|
3 (13.0)
| |
17 (40.5)
|
7 (50.0)
|
12 (31.6)
|
201 (32.1)
| |
|
Tumor stage
| | | | |
0.495
| | | | |
0.640
|
|
T1
|
329 (48.5)
|
0 (0.0)
|
6 (33.3)
|
15 (65.2)
| |
20 (47.6)
|
7 (50.0)
|
24 (63.2)
|
299 (47.7)
| |
|
T2/T3
|
350 (51.5)
|
1 (100.0)
|
12 (66.7)
|
8 (34.8)
| |
22 (52.4)
|
7 (50.0)
|
14 (36.8)
|
328 (52.3)
| |
|
Nodal stage
| | | | |
0.491
| | | | |
0.314
|
|
N0
|
398 (58.6)
|
1 (100.0)
|
11 (61.1)
|
15 (65.2)
| |
21 (50.0)
|
10 (71.4)
|
20 (52.6)
|
374 (59.6)
| |
|
N1/N2/N3
|
281 (41.4)
|
0 (0.0)
|
7 (38.9)
|
8 (34.8)
| |
21 (50.0)
|
4 (28.6)
|
18 (47.4)
|
253 (40.4)
| |
|
ER
| | | | |
0.284
| | | | |
0.205
|
|
Negative
|
248 (36.5)
|
1 (100.0)
|
7 (38.9)
|
5 (21.7)
| |
16 (38.1)
|
10 (71.4)
|
14 (36.8)
|
221 (35.2)
| |
|
Positive
|
431 (63.5)
|
0 (0.0)
|
11 (61.1)
|
18 (78.3)
| |
26 (61.9)
|
4 (28.6)
|
24 (63.2)
|
406 (64.8)
| |
|
PR
| | | | |
0.793
| | | | |
0.336
|
|
Negative
|
324 (47.7)
|
1 (100.0)
|
11 (61.1)
|
10 (43.5)
| |
21 (50.0)
|
11 (78.6)
|
17 (44.7)
|
297 (47.4)
| |
|
Positive
|
355 (52.3)
|
0 (0.0)
|
7 (38.9)
|
13 (56.5)
| |
21 (50.0)
|
3 (21.4)
|
21 (55.3)
|
330 (52.6)
| |
|
HER-2
| | | | |
0.567
| | | | |
0.001
|
|
Negative
|
539 (79.4)
|
0 (0.0)
|
14 (77.8)
|
20 (87.0)
| |
26 (61.9)
|
13 (92.9)
|
21 (55.3)
|
513 (81.8)
| |
|
Positive
|
140 (20.6)
|
1 (100.0)
|
4 (22.2)
|
3 (13.0)
| |
16 (38.1)
|
1 (7.1)
|
17 (44.7)
|
114 (18.2)
| |
|
Molecular type
| | | | |
0.057
| | | | |
<0.001
|
|
Luminal A
|
281 (41.4)
|
0 (0.0)
|
6 (33.3)
|
15 (65.2)
| |
14 (33.3)
|
2 (14.3)
|
11 (28.9)
|
275 (43.9)
| |
|
Luminal B
|
160 (23.6)
|
0 (0.0)
|
5 (27.8)
|
3 (13.0)
| |
13 (31.0)
|
2 (14.3)
|
13 (34.2)
|
140 (22.3)
| |
|
HER-2
|
63 (9.3)
|
1 (100.0)
|
3 (16.7)
|
2 (8.7)
| |
9 (21.4)
|
1 (7.1)
|
9 (23.7)
|
50 (8.0)
| |
|
TNBC
|
175 (25.8)
|
0 (0.0)
|
4 (22.2)
|
3 (13.0)
| |
6 (14.3)
|
9 (64.3)
|
5 (13.2)
|
162 (25.8)
| |
|
Ki-67 LI (%, mean ± SD)
|
17.5 ± 18.7
|
8.0 ± 0.0
|
16.8 ± 14.0
|
10.0 ± 10.2
|
0.260
|
17.8 ± 15.3
|
24.3 ± 22.8
|
22.1 ± 19.0
|
16.8 ± 18.4
|
0.161
|
|
Tumor recurrence
|
59 (8.7)
|
0 (0.0)
|
3 (16.7)
|
1 (4.3)
|
0.955
|
4 (9.5)
|
1 (7.1)
|
2 (5.3)
|
56 (8.9)
|
0.877
|
|
Patient death
|
56 (8.2)
|
0 (0.0)
|
3 (16.7)
|
1 (4.3)
|
0.968
|
3 (7.1)
|
1 (7.1)
|
3 (7.9)
|
53 (8.5)
|
0.727
|
- SDH succinate dehydrogenase.
