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Table 7 Clinicopathologic features according to the SDH expression phenotype in breast cancer

From: Succinate dehydrogenase expression in breast cancer

Factors Tumor phenotype Stroma phenotype
SDHA (+)/ SDHB SDHA (+)/ SDHB SDHA (−)/ SDHB SDHA (-)/ SDHB P SDHA (+)/ SDHB SDHA (+)/ SDHB SDHA (−)/ SDHB SDHA (−)/ SDHB P
(+) n = 679 (%) (−) n = 1 (%) (+) n = 18 (%) (−) n = 23 (%) (+) n = 42 (%) (−) n = 14 (%) (+) n = 38 (%) (−) n = 627 (%)
Histologic grade      0.038      0.150
 I/II 450 (66.3) 1 (100.0) 13 (72.2) 20 (87.0)   25 (59.5) 7 (50.0) 26 (68.4) 426 (67.9)  
 III 229 (33.7) 0 (0.0) 5 (27.8) 3 (13.0)   17 (40.5) 7 (50.0) 12 (31.6) 201 (32.1)  
Tumor stage      0.495      0.640
 T1 329 (48.5) 0 (0.0) 6 (33.3) 15 (65.2)   20 (47.6) 7 (50.0) 24 (63.2) 299 (47.7)  
 T2/T3 350 (51.5) 1 (100.0) 12 (66.7) 8 (34.8)   22 (52.4) 7 (50.0) 14 (36.8) 328 (52.3)  
Nodal stage      0.491      0.314
 N0 398 (58.6) 1 (100.0) 11 (61.1) 15 (65.2)   21 (50.0) 10 (71.4) 20 (52.6) 374 (59.6)  
 N1/N2/N3 281 (41.4) 0 (0.0) 7 (38.9) 8 (34.8)   21 (50.0) 4 (28.6) 18 (47.4) 253 (40.4)  
ER      0.284      0.205
 Negative 248 (36.5) 1 (100.0) 7 (38.9) 5 (21.7)   16 (38.1) 10 (71.4) 14 (36.8) 221 (35.2)  
 Positive 431 (63.5) 0 (0.0) 11 (61.1) 18 (78.3)   26 (61.9) 4 (28.6) 24 (63.2) 406 (64.8)  
PR      0.793      0.336
 Negative 324 (47.7) 1 (100.0) 11 (61.1) 10 (43.5)   21 (50.0) 11 (78.6) 17 (44.7) 297 (47.4)  
 Positive 355 (52.3) 0 (0.0) 7 (38.9) 13 (56.5)   21 (50.0) 3 (21.4) 21 (55.3) 330 (52.6)  
HER-2      0.567      0.001
 Negative 539 (79.4) 0 (0.0) 14 (77.8) 20 (87.0)   26 (61.9) 13 (92.9) 21 (55.3) 513 (81.8)  
 Positive 140 (20.6) 1 (100.0) 4 (22.2) 3 (13.0)   16 (38.1) 1 (7.1) 17 (44.7) 114 (18.2)  
Molecular type      0.057      <0.001
 Luminal A 281 (41.4) 0 (0.0) 6 (33.3) 15 (65.2)   14 (33.3) 2 (14.3) 11 (28.9) 275 (43.9)  
 Luminal B 160 (23.6) 0 (0.0) 5 (27.8) 3 (13.0)   13 (31.0) 2 (14.3) 13 (34.2) 140 (22.3)  
 HER-2 63 (9.3) 1 (100.0) 3 (16.7) 2 (8.7)   9 (21.4) 1 (7.1) 9 (23.7) 50 (8.0)  
 TNBC 175 (25.8) 0 (0.0) 4 (22.2) 3 (13.0)   6 (14.3) 9 (64.3) 5 (13.2) 162 (25.8)  
Ki-67 LI (%, mean ± SD) 17.5 ± 18.7 8.0 ± 0.0 16.8 ± 14.0 10.0 ± 10.2 0.260 17.8 ± 15.3 24.3 ± 22.8 22.1 ± 19.0 16.8 ± 18.4 0.161
Tumor recurrence 59 (8.7) 0 (0.0) 3 (16.7) 1 (4.3) 0.955 4 (9.5) 1 (7.1) 2 (5.3) 56 (8.9) 0.877
Patient death 56 (8.2) 0 (0.0) 3 (16.7) 1 (4.3) 0.968 3 (7.1) 1 (7.1) 3 (7.9) 53 (8.5) 0.727
  1. SDH succinate dehydrogenase.