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Table 6 Clinicopathologic characteristics breast cancer by expression of HIF-1α and SDH

From: Succinate dehydrogenase expression in breast cancer

Parameters Nuclear HIF-1α Cytoplasmic HIF-1α Tumor SDHA Stromal SDHA Tumor SDHB Stromal SDHB
- + P - + P -* + P - + P -* + P - + P
Histologic grade    0.270    0.601    0.342    0.105    0.870    0.528
 I/II 465 (66.7) 19 (79.2)   482 (67.2) 2 (50.0)   248 (68.9) 236 (65.4)   452 (68.0) 32 (57.1)   182 (67.7) 302 (66.8)   433 (67.6) 51 (63.8)  
 III 232 (33.3) 5 (20.8)   235 (32.8) 2 (50.0)   112 (31.2) 125 (34.6)   213 (32.0) 24 (42.9)   87 (32.3) 150 (33.2)   208 (32.4) 29 (36.3)  
ER    0.388    1.000    0.044    0.111    0.873    0.806
 Negative 250 (35.9) 11 (45.8)   260 (36.3) 1 (25.0)   117 (32.5) 144 (39.9)   235 (35.3) 26 (46.4)   96 (35.7) 165 (36.5)   231 (36.0) 30 (37.5)  
 Positive 447 (64.1) 13 (54.2)   457 (63.7) 3 (75.0)   243 (67.5) 217 (60.1)   430 (64.7) 30 (53.6)   173 (64.3) 287 (63.5)   410 (64.0) 50 (62.5)  
PR    0.011    1.000    0.118    0.165    0.645    1.000
 Negative 328 (47.1) 18 (75.0)   344 (48.0) 2 (50.0)   162 (45.0) 184 (51.0)   314 (47.2) 32 (57.1)   126 (46.8) 220 (48.7)   308 (48.0) 38 (47.5)  
 Positive 369 (52.9) 6 (25.0)   373 (52.0) 2 (50.0)   198 (55.0) 177 (49.0)   351 (52.8) 24 (42.9)   143 (53.2) 232 (51.3)   333 (52.0) 42 (52.5)  
HER-2    0.304    1.000    0.021    0.083    0.057    <0.001
 Negative 556 (79.8) 17 (70.8)   570 (79.5) 3 (75.0)   299 (83.1) 274 (75.9)   534 (80.3) 39 (69.6)   224 (83.3) 349 (77.2)   526 (82.1) 47 (58.8)  
 Positive 141 (20.2) 7 (29.2)   147 (20.5) 1 (25.0)   61 (16.9) 87 (24.1)   131 (19.7) 17 (30.4)   45 (16.7) 103 (22.8)   115 (17.9) 33 (41.3)  
Tumor stage    0.304    1.000    0.031    1.000    0.011    0.237
 T1 341 (48.9) 9 (37.5)   348 (48.5) 2 (50.0)   160 (44.4) 190 (52.6)   323 (48.6) 27 (48.2)   114 (42.4) 236 (52.2)   306 (47.7) 44 (55.0)  
 T2/T3 356 (51.1) 15 (62.5)   369 (51.5) 2 (50.0)   200 (55.6) 171 (47.4)   342 (51.4) 29 (51.8)   155 (57.6) 216 (47.8)   335 (52.3) 36 (45.0)  
Nodal stage    0.208    0.648    0.198    0.575    0.639    0.149
 N0 414 (59.4) 11 (45.8)   422 (58.9) 3 (75.0)   221 (61.4) 204 (56.5)   394 (59.2) 31 (55.4)   162 (60.2) 263 (58.2)   384 (59.9) 41 (51.3)  
 N1/N2/N3 283 (40.6) 13 (54.2)   295 (41.1) 1 (25.0)   139 (38.6) 157 (43.5)   271 (40.8) 25 (44.6)   107 (39.8) 189 (41.8)   257 (40.1) 39 (48.8)  
  1. SDH succinate dehydrogenase.
  2. *includes negative and low-positive cases.