Table 6 Clinicopathologic characteristics breast cancer by expression of HIF-1α and SDH
Parameters | Nuclear HIF-1α | Cytoplasmic HIF-1α | Tumor SDHA | Stromal SDHA | Tumor SDHB | Stromal SDHB | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
- | + | P | - | + | P | -* | + | P | - | + | P | -* | + | P | - | + | P | |
Histologic grade | 0.270 | 0.601 | 0.342 | 0.105 | 0.870 | 0.528 | ||||||||||||
I/II | 465 (66.7) | 19 (79.2) | 482 (67.2) | 2 (50.0) | 248 (68.9) | 236 (65.4) | 452 (68.0) | 32 (57.1) | 182 (67.7) | 302 (66.8) | 433 (67.6) | 51 (63.8) | ||||||
III | 232 (33.3) | 5 (20.8) | 235 (32.8) | 2 (50.0) | 112 (31.2) | 125 (34.6) | 213 (32.0) | 24 (42.9) | 87 (32.3) | 150 (33.2) | 208 (32.4) | 29 (36.3) | ||||||
ER | 0.388 | 1.000 | 0.044 | 0.111 | 0.873 | 0.806 | ||||||||||||
Negative | 250 (35.9) | 11 (45.8) | 260 (36.3) | 1 (25.0) | 117 (32.5) | 144 (39.9) | 235 (35.3) | 26 (46.4) | 96 (35.7) | 165 (36.5) | 231 (36.0) | 30 (37.5) | ||||||
Positive | 447 (64.1) | 13 (54.2) | 457 (63.7) | 3 (75.0) | 243 (67.5) | 217 (60.1) | 430 (64.7) | 30 (53.6) | 173 (64.3) | 287 (63.5) | 410 (64.0) | 50 (62.5) | ||||||
PR | 0.011 | 1.000 | 0.118 | 0.165 | 0.645 | 1.000 | ||||||||||||
Negative | 328 (47.1) | 18 (75.0) | 344 (48.0) | 2 (50.0) | 162 (45.0) | 184 (51.0) | 314 (47.2) | 32 (57.1) | 126 (46.8) | 220 (48.7) | 308 (48.0) | 38 (47.5) | ||||||
Positive | 369 (52.9) | 6 (25.0) | 373 (52.0) | 2 (50.0) | 198 (55.0) | 177 (49.0) | 351 (52.8) | 24 (42.9) | 143 (53.2) | 232 (51.3) | 333 (52.0) | 42 (52.5) | ||||||
HER-2 | 0.304 | 1.000 | 0.021 | 0.083 | 0.057 | <0.001 | ||||||||||||
Negative | 556 (79.8) | 17 (70.8) | 570 (79.5) | 3 (75.0) | 299 (83.1) | 274 (75.9) | 534 (80.3) | 39 (69.6) | 224 (83.3) | 349 (77.2) | 526 (82.1) | 47 (58.8) | ||||||
Positive | 141 (20.2) | 7 (29.2) | 147 (20.5) | 1 (25.0) | 61 (16.9) | 87 (24.1) | 131 (19.7) | 17 (30.4) | 45 (16.7) | 103 (22.8) | 115 (17.9) | 33 (41.3) | ||||||
Tumor stage | 0.304 | 1.000 | 0.031 | 1.000 | 0.011 | 0.237 | ||||||||||||
T1 | 341 (48.9) | 9 (37.5) | 348 (48.5) | 2 (50.0) | 160 (44.4) | 190 (52.6) | 323 (48.6) | 27 (48.2) | 114 (42.4) | 236 (52.2) | 306 (47.7) | 44 (55.0) | ||||||
T2/T3 | 356 (51.1) | 15 (62.5) | 369 (51.5) | 2 (50.0) | 200 (55.6) | 171 (47.4) | 342 (51.4) | 29 (51.8) | 155 (57.6) | 216 (47.8) | 335 (52.3) | 36 (45.0) | ||||||
Nodal stage | 0.208 | 0.648 | 0.198 | 0.575 | 0.639 | 0.149 | ||||||||||||
N0 | 414 (59.4) | 11 (45.8) | 422 (58.9) | 3 (75.0) | 221 (61.4) | 204 (56.5) | 394 (59.2) | 31 (55.4) | 162 (60.2) | 263 (58.2) | 384 (59.9) | 41 (51.3) | ||||||
N1/N2/N3 | 283 (40.6) | 13 (54.2) | 295 (41.1) | 1 (25.0) | 139 (38.6) | 157 (43.5) | 271 (40.8) | 25 (44.6) | 107 (39.8) | 189 (41.8) | 257 (40.1) | 39 (48.8) | ||||||