Table 5 Clinicopathologic characteristics of breast cancer with SDHA and/or SDHB negativity in tumor cells
Parameters | SDHA | SDHB | ||||
|---|---|---|---|---|---|---|
Negative n = 41 (%) | Positive n = 680 (%) | P-value | Negative n = 24 (%) | Positive n = 697 (%) | P-value | |
Age (years, mean ± SD) | 45.4 ± 10.3 | 49.9 ± 10.9 | 0.012 | 46.9 ± 9.1 | 49.7 ± 10.9 | 0.212 |
Histologic grade | 0.062 | 0.044 | ||||
I/II | 33 (80.5) | 451 (66.3) | 21 (87.5) | 463 (66.4) | ||
III | 8 (19.5) | 229 (33.7) | 3 (12.5) | 234 (33.6) | ||
ER | 0.405 | 0.286 | ||||
Negative | 12 (29.3) | 249 (36.6) | 6 (25.0) | 255 (36.6) | ||
Positive | 29 (70.7) | 431 (63.4) | 18 (75.0) | 442 (63.4) | ||
PR | 0.748 | 1.000 | ||||
Negative | 21 (51.2) | 325 (47.8) | 11 (45.8) | 335 (48.1) | ||
Positive | 20 (48.8) | 355 (52.2) | 13 (54.2) | 362 (51.9) | ||
HER-2 | 0.693 | 0.800 | ||||
Negative | 34 (82.9) | 539 (79.3) | 20 (83.3) | 553 (79.3) | ||
Positive | 7 (17.1) | 141 (20.7) | 4 (16.7) | 144 (20.7) | ||
Tumor stage | 0.750 | 0.213 | ||||
T1 | 21 (51.2) | 329 (48.4) | 15 (62.5) | 335 (48.1) | ||
T2/T3 | 20 (48.8) | 351 (51.6) | 9 (37.5) | 362 (51.9) | ||
Nodal stage | 0.625 | 0.529 | ||||
N0 | 26 (63.4) | 399 (58.7) | 16 (66.7) | 409 (58.7) | ||
N1/N2/N3 | 15 (36.6) | 281 (41.3) | 8 (33.3) | 288 (41.3) | ||
Molecular subtypes | 0.452 | 0.134 | ||||
Luminal A | 21 (51.2) | 281 (41.3) | 15 (62.5) | 287 (41.2) | ||
Luminal B | 8 (19.5) | 160 (23.5) | 3 (12.5) | 165 (23.7) | ||
HER-2 | 5 (12.2) | 64 (9.4) | 3 (12.5) | 66 (9.5) | ||
TNBC | 7 (17.1) | 175 (25.7) | 3 (12.5) | 179 (25.7) | ||
Ki-67 LI (%, mean ± SD) | 13.0 ± 12.3 | 17.5 ± 18.7 | 0.127 | 9.9 ± 10.0 | 17.5 ± 18.6 | 0.046 |
Tumor recurrence | 4 (9.8) | 59 (8.7) | 0.775 | 1 (4.2) | 62 (8.9) | 0.714 |
Patient death | 4 (9.8) | 56 (8.2) | 0.768 | 1 (4.2) | 59 (8.5) | 0.713 |