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Table 5 Clinicopathologic characteristics of breast cancer with SDHA and/or SDHB negativity in tumor cells

From: Succinate dehydrogenase expression in breast cancer

Parameters SDHA SDHB
Negative n = 41 (%) Positive n = 680 (%) P-value Negative n = 24 (%) Positive n = 697 (%) P-value
Age (years, mean ± SD) 45.4 ± 10.3 49.9 ± 10.9 0.012 46.9 ± 9.1 49.7 ± 10.9 0.212
Histologic grade    0.062    0.044
 I/II 33 (80.5) 451 (66.3)   21 (87.5) 463 (66.4)  
 III 8 (19.5) 229 (33.7)   3 (12.5) 234 (33.6)  
ER    0.405    0.286
 Negative 12 (29.3) 249 (36.6)   6 (25.0) 255 (36.6)  
 Positive 29 (70.7) 431 (63.4)   18 (75.0) 442 (63.4)  
PR    0.748    1.000
 Negative 21 (51.2) 325 (47.8)   11 (45.8) 335 (48.1)  
 Positive 20 (48.8) 355 (52.2)   13 (54.2) 362 (51.9)  
HER-2    0.693    0.800
 Negative 34 (82.9) 539 (79.3)   20 (83.3) 553 (79.3)  
 Positive 7 (17.1) 141 (20.7)   4 (16.7) 144 (20.7)  
Tumor stage    0.750    0.213
 T1 21 (51.2) 329 (48.4)   15 (62.5) 335 (48.1)  
 T2/T3 20 (48.8) 351 (51.6)   9 (37.5) 362 (51.9)  
Nodal stage    0.625    0.529
 N0 26 (63.4) 399 (58.7)   16 (66.7) 409 (58.7)  
 N1/N2/N3 15 (36.6) 281 (41.3)   8 (33.3) 288 (41.3)  
Molecular subtypes    0.452    0.134
 Luminal A 21 (51.2) 281 (41.3)   15 (62.5) 287 (41.2)  
 Luminal B 8 (19.5) 160 (23.5)   3 (12.5) 165 (23.7)  
 HER-2 5 (12.2) 64 (9.4)   3 (12.5) 66 (9.5)  
 TNBC 7 (17.1) 175 (25.7)   3 (12.5) 179 (25.7)  
Ki-67 LI (%, mean ± SD) 13.0 ± 12.3 17.5 ± 18.7 0.127 9.9 ± 10.0 17.5 ± 18.6 0.046
Tumor recurrence 4 (9.8) 59 (8.7) 0.775 1 (4.2) 62 (8.9) 0.714
Patient death 4 (9.8) 56 (8.2) 0.768 1 (4.2) 59 (8.5) 0.713
  1. SDH succinate dehydrogenase, TNBC triple negative breast cancer.