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Table 4 Expression of SDHA and SDHB according to HIF-1α expression status

From: Succinate dehydrogenase expression in breast cancer

Factors Nuclear HIF-1α Cytoplasmic HIF-1α
Negative n = 697 (%) Positive n = 24 (%) P-value Negative n = 717 (%) Positive n = 4 (%) P-value
Tumoral SDHA    0.247    0.518
 Negative 40 (5.7) 1 (4.2)   40 (5.6) 1 (25.0)  
 Low 311 (44.6) 8 (33.3)   318 (44.4) 1 (25.0)  
 High 346 (49.6) 15 (62.5)   359 (50.1) 50.0)  
Stromal SDHA    0.423    1.000
 Negative 644 (92.4) 21 (87.5)   661 (92.2) 4 (100.0)  
 Positive 53 (7.6) 3 (12.5)   56 (7.8) 0 (0.0)  
Tumoral SDHB    0.926    0.032
 Negative 24 (3.4) 0 (0.0)   23 (3.2) 1 (25.0)  
 Low 235 (33.7) 10 (41.7)   243 (33.9) 2 (50.0)  
 High 438 (62.8) 14 (58.3)   451 (62.9) 1 (25.0)  
Stromal SDHB    0.328    1.000
 Negative 621 (89.1) 20 (83.3)   637 (88.8) 4 (100.0)  
 Positive 76 (10.9) 4 (16.7)   80 (11.2) 0 (0.0)  
  1. SDH succinate dehydrogenase.