|
Factors
|
Nuclear HIF-1α
|
Cytoplasmic HIF-1α
|
|---|
|
Negative n = 697 (%)
|
Positive n = 24 (%)
|
P-value
|
Negative n = 717 (%)
|
Positive n = 4 (%)
|
P-value
|
|---|
|
Tumoral SDHA
| | |
0.247
| | |
0.518
|
|
Negative
|
40 (5.7)
|
1 (4.2)
| |
40 (5.6)
|
1 (25.0)
| |
|
Low
|
311 (44.6)
|
8 (33.3)
| |
318 (44.4)
|
1 (25.0)
| |
|
High
|
346 (49.6)
|
15 (62.5)
| |
359 (50.1)
|
50.0)
| |
|
Stromal SDHA
| | |
0.423
| | |
1.000
|
|
Negative
|
644 (92.4)
|
21 (87.5)
| |
661 (92.2)
|
4 (100.0)
| |
|
Positive
|
53 (7.6)
|
3 (12.5)
| |
56 (7.8)
|
0 (0.0)
| |
|
Tumoral SDHB
| | |
0.926
| | |
0.032
|
|
Negative
|
24 (3.4)
|
0 (0.0)
| |
23 (3.2)
|
1 (25.0)
| |
|
Low
|
235 (33.7)
|
10 (41.7)
| |
243 (33.9)
|
2 (50.0)
| |
|
High
|
438 (62.8)
|
14 (58.3)
| |
451 (62.9)
|
1 (25.0)
| |
|
Stromal SDHB
| | |
0.328
| | |
1.000
|
|
Negative
|
621 (89.1)
|
20 (83.3)
| |
637 (88.8)
|
4 (100.0)
| |
|
Positive
|
76 (10.9)
|
4 (16.7)
| |
80 (11.2)
|
0 (0.0)
| |
- SDH succinate dehydrogenase.
