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Table 3 Expression of HIF-1α and SDH according to tumor phenotype

From: Succinate dehydrogenase expression in breast cancer

Parameters Total n = 721 (%) Luminal A n = 302 (%) Luminal B n = 168 (%) HER-2 n = 69 (%) TNBC n = 182 (%) P-value
Nuclear HIF-1α       0.319
 Negative 697 (96.7) 296 (98.0) 161 (95.8) 65 (94.2) 175 (96.2)  
 Positive 24 (3.3) 6 (2.0) 7 (4.2) 4 (5.8) 7 (3.8)  
Cytoplasmic HIF-1α       0.596
 Negative 717 (99.4) 301 (99.7) 166 (98.8) 69 (100.0) 181 (99.5)  
 Positive 4 (0.6) 1 (0.3) 2 (1.2) 0 (0.0) 1 (0.5)  
Tumoral SDHA       0.032
 Negative/Low 41/319 (49.9) 21/143 (54.3) 8/76 (50.0) 5/19 (34.8) 7/81 (48.4)  
 High 361 (50.1) 138 (45.7) 84 (50.0) 45 (65.2) 94 (51.6)  
Stromal SDHA       0.063
 Negative 665 (92.2) 286 (94.7) 153 (91.1) 59 (85.5) 167 (91.8)  
 Positive 56 (7.8) 16 (5.3) 15 (8.9) 10 (14.5) 15 (8.2)  
Tumoral SDHB       0.291
 Negative/Low 24/245 (37.3) 15/103 (39.1) 3/56 (35.1) 3/19 (31.9) 3/67 (38.5)  
 High 452 (62.7) 184 (60.9) 109 (64.9) 47 (68.1) 112 (61.5)  
Stromal SDHB       <0.001
 Negative 641 (88.9) 277 (91.7) 142 (84.5) 51 (73.9) 171 (94.0)  
 Positive 80 (11.1) 25 (8.3) 26 (15.5) 18 (26.1) 11 (6.0)  
  1. TNBC triple negative breast cancer.