Table 3 Expression of HIF-1α and SDH according to tumor phenotype
Parameters | Total n = 721 (%) | Luminal A n = 302 (%) | Luminal B n = 168 (%) | HER-2 n = 69 (%) | TNBC n = 182 (%) | P-value |
|---|---|---|---|---|---|---|
Nuclear HIF-1α | 0.319 | |||||
Negative | 697 (96.7) | 296 (98.0) | 161 (95.8) | 65 (94.2) | 175 (96.2) | |
Positive | 24 (3.3) | 6 (2.0) | 7 (4.2) | 4 (5.8) | 7 (3.8) | |
Cytoplasmic HIF-1α | 0.596 | |||||
Negative | 717 (99.4) | 301 (99.7) | 166 (98.8) | 69 (100.0) | 181 (99.5) | |
Positive | 4 (0.6) | 1 (0.3) | 2 (1.2) | 0 (0.0) | 1 (0.5) | |
Tumoral SDHA | 0.032 | |||||
Negative/Low | 41/319 (49.9) | 21/143 (54.3) | 8/76 (50.0) | 5/19 (34.8) | 7/81 (48.4) | |
High | 361 (50.1) | 138 (45.7) | 84 (50.0) | 45 (65.2) | 94 (51.6) | |
Stromal SDHA | 0.063 | |||||
Negative | 665 (92.2) | 286 (94.7) | 153 (91.1) | 59 (85.5) | 167 (91.8) | |
Positive | 56 (7.8) | 16 (5.3) | 15 (8.9) | 10 (14.5) | 15 (8.2) | |
Tumoral SDHB | 0.291 | |||||
Negative/Low | 24/245 (37.3) | 15/103 (39.1) | 3/56 (35.1) | 3/19 (31.9) | 3/67 (38.5) | |
High | 452 (62.7) | 184 (60.9) | 109 (64.9) | 47 (68.1) | 112 (61.5) | |
Stromal SDHB | <0.001 | |||||
Negative | 641 (88.9) | 277 (91.7) | 142 (84.5) | 51 (73.9) | 171 (94.0) | |
Positive | 80 (11.1) | 25 (8.3) | 26 (15.5) | 18 (26.1) | 11 (6.0) |