|
Parameters
|
Total n = 721 (%)
|
Luminal A n = 302 (%)
|
Luminal B n = 168 (%)
|
HER-2 n = 69 (%)
|
TNBC n = 182 (%)
|
P-value
|
|---|
|
Nuclear HIF-1α
| | | | | |
0.319
|
|
Negative
|
697 (96.7)
|
296 (98.0)
|
161 (95.8)
|
65 (94.2)
|
175 (96.2)
| |
|
Positive
|
24 (3.3)
|
6 (2.0)
|
7 (4.2)
|
4 (5.8)
|
7 (3.8)
| |
|
Cytoplasmic HIF-1α
| | | | | |
0.596
|
|
Negative
|
717 (99.4)
|
301 (99.7)
|
166 (98.8)
|
69 (100.0)
|
181 (99.5)
| |
|
Positive
|
4 (0.6)
|
1 (0.3)
|
2 (1.2)
|
0 (0.0)
|
1 (0.5)
| |
|
Tumoral SDHA
| | | | | |
0.032
|
|
Negative/Low
|
41/319 (49.9)
|
21/143 (54.3)
|
8/76 (50.0)
|
5/19 (34.8)
|
7/81 (48.4)
| |
|
High
|
361 (50.1)
|
138 (45.7)
|
84 (50.0)
|
45 (65.2)
|
94 (51.6)
| |
|
Stromal SDHA
| | | | | |
0.063
|
|
Negative
|
665 (92.2)
|
286 (94.7)
|
153 (91.1)
|
59 (85.5)
|
167 (91.8)
| |
|
Positive
|
56 (7.8)
|
16 (5.3)
|
15 (8.9)
|
10 (14.5)
|
15 (8.2)
| |
|
Tumoral SDHB
| | | | | |
0.291
|
|
Negative/Low
|
24/245 (37.3)
|
15/103 (39.1)
|
3/56 (35.1)
|
3/19 (31.9)
|
3/67 (38.5)
| |
|
High
|
452 (62.7)
|
184 (60.9)
|
109 (64.9)
|
47 (68.1)
|
112 (61.5)
| |
|
Stromal SDHB
| | | | | |
<0.001
|
|
Negative
|
641 (88.9)
|
277 (91.7)
|
142 (84.5)
|
51 (73.9)
|
171 (94.0)
| |
|
Positive
|
80 (11.1)
|
25 (8.3)
|
26 (15.5)
|
18 (26.1)
|
11 (6.0)
| |
- TNBC triple negative breast cancer.
