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Table 2 The parameter set defining the interactive network model

From: Interactive network analysis of the plasma amino acids profile in a mouse model of hyperglycemia

(Ins2+/+, Ins2+/−) g ij   h ij
   j   j
i α Val Leu Ile Ala Gly β Val Leu Ile Ala Gly
Val (1.5, 4.4) (0, 0) (−0.2, -0.7) (0, 0) (2.0, 0.6) (−1.8, 0.1) (1.0, 1.5) (0, 0.01) (0, 0) (0, 0) (0, 0) (0, 0)
Leu (7.5, 4.8) (0, 0) (0, 0) (0, 0) (−1.3, -1.0) (1.4, 1.2) (1.2, 1.0) (0, 0) (0, 0) (0, 0) (0, 0) (0, 0)
Ile (7.6, 3.8) (0, 0) (−0.1, -1.3) (0, 0) (−2.3, 0.4) (2.5, 0.8) (1.1,1.5) (0, 0) (0, 0) (0, 0) (0, 0) (0, 0)
Ala (7.4, 4.6) (0.8, -0.6) (−1.7, 1.0) (2.6, 0.9) (0, 0) (−0.9, -1.1) (1.2, 1.5) (0, 0) (0, 0) (0, 0) (0.7,0) (0, 0)
Gly (8.8, 2.8) (2.4, 1.2) (−2.3, -1.1) (−1.9, -1.5) (2.1, 1.7) (0, 0) (1.2, 5.6) (0, 0) (0, 0) (0, 0) (0, 0) (1.3, 0.8)
  1. The interrelated coefficient of each path in the network model (left: Ins2+/+, right: Ins2+/−) is indicated as a matrix in which the amino acid giving the influence (j) is indicated in the top row and the amino acid receiving the effect (i) is indicated in the left column. The variable gij indicates the effect between each pair of amino acids, and hij indicates the speed of degradation for each amino acid. The parameters with value 0 indicate that there is no relationship between the two amino acids.