Figure 4

The network model defined by the parameter set in Table 2 . The arrows indicate positive effects, and the lines with bars indicate negative effects. The numbers adjacent to the lines indicate the interrelated coefficient of each path. Red arrows and lines with bars indicate the difference between Ins2+/+ and Ins2+/−. A. Ins2+/+ network model defined by the parameter set in Table 2. B. Ins2+/− network model defined by the parameter set in Table 2. Relative sensitivity of each of the parameters in the network model. The arrows indicate positive effects from amino acids on the left to amino acids on the right, and the bars indicate negative effects from amino acids on the left to amino acids on the right. C. Ins2+/+ relative sensitivity of each of the parameters in the network model. D. Ins2+/− relative sensitivity of each of the parameters in the network model.