Food intake and the changes in weight in Ins2+/+ and Ins2+/−. A. Bar graph for the food intake in Ins2+/− and Ins2+/+. The vertical axis indicates the food intake (g/day). The horizontal axis indicates the age (week). Data are the mean ± SEM. The white bar indicates Ins2+/+ (n = 3). The black bar indicates Ins2+/− (n = 3). Food intake was lower in Ins2+/−. *p < 0.05, Ins2+/− vs. Ins2+/+. B. Line graph for the change in weight from 3 to 20 weeks of age. The vertical axis indicates the body weight (g). The horizontal axis indicates the age (week). Data are means ± SEM. The solid line indicates Ins2+/− (n = 9–13). The dotted line indicates Ins2+/+. (n = 12). * p < 0.05, ** p < 0.01, Ins2+/− vs. Ins2+/+. This figure was revised based on our previous study (Mochida et al. 2011).