Figure 1

Administration of LFK protects mice from influenza virus PR8-induced death. (A) The experimental protocol for oral administration and infection with influenza A/PR/8. The vertical arrows indicate oral administration of LFK (15 mg/head, dissolved in 200 μl saline) or saline from day -6 to day 17. The triangle on day 0 indicates the inoculation with PR8 (1,000 PFU/mouse). (B) Survival rate of mice after the infection with PR8 (saline-administered group: circle, n = 19; LFK-administered group: triangle, n = 20). Statistically significant difference between saline and control mice is indicated by P value (P < 0.05 by the log-rank test). (C) Viral titers in the lungs after inoculation with PR8. Mean viral titers ± standard deviations are shown. Each group consists of 6 to 7 mice.