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Table 4 Stepwise logistic regression analysis of the factors related to PNPLA3 148 M

From: Predictive impact of polymorphism of PNPLA3 on HCC development after interferon therapy in Japanese patients with chronic hepatitis C

  Univariate analysis Multivariate analysis
Factors Odds ratio (range) p Odds ratio (range) p
Age (years) 0.98 (0.95-1.0) 0.12   
Sex (1: male) 0.69 (0.41-1.2) 0.17   
Body mass index 1.0 (0.93-1.1) 0.73   
Liver fibrosis 0.68 (0.48-0.96) 0.028 0.78 (0.54-1.1) 0.20
Hepatitis activity 1.3 (0.70-2.3) 0.43   
Liver steatosis (1: >30%) 0.96 (0.55-1.7) 0.87   
Amino acid 70 of HCV core (1: glutamine) 0.80 (0.38-1.7) 0.56   
Alanine aminotransferase (1: >40 IU/L) 0.72 (0.51-1.0) 0.068   
Platelet count (1: >1.5x105/mm3) 2.1 (0.93-4.7) 0.076   
Alpha fetoprotein (1: >5 ng/mL) 0.36 (0.20-0.65) 0.0007 0.42 (0.21-0.85) 0.017
HOMA-IR 0.18 (0.92-1.0) 0.18   
  1. : 95% confidence interval; PNPLA3, patatin-like phospholipase domain-containing protein 3; HOMA-IR, homeostasis model assessment insulin resistance.