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Table 3 Stepwise logistic regression analysis of the factors related to alpha fetoprotein > 5 ng/mL

From: Predictive impact of polymorphism of PNPLA3 on HCC development after interferon therapy in Japanese patients with chronic hepatitis C

  Univariate analysis Multivariate analysis
Factors Odds ratio (range) p Odds ratio (range) p
Age (years) 1.0 (1.0-1.1) 0.0024 1.0 (1.0-1.1) 0.064
Sex (1:male) 0.95 (0.58-1.6) 0.84   
Body mass index 1.2 (1.1-1.3) 0.0005 1.2 (1.1-1.3) 0.0006
Liver fibrosis 2.8 (1.9-4.2) <0.0001   
Hepatitis activity 1.1 (0.61-1.9) 0.83   
Liver steatosis (1: >30%) 1.8 (1.1-3.0) 0.026 1.3 (0.72-2.4) 0.37
rs 8099917 of IL28B (1: TT) 1.1 (0.65-2.0) 0.67   
rs738409 of PNPLA3 (1: 148 M) 0.36 (0.20-0.65) 0.0007 0.46 (0.22-0.93) 0.032
Amino acid 70 of HCV core (1: glutamine) 1.1 (0.58-2.2) 0.71   
Alanine aminotransferase (1: >40 IU/L) 2.3 (1.6-3.3) <0.0001 1.6 (1.0-2.4) 0.037
Platelet count (1: >1.5x105/mm3) 0.33 (0.22-0.50) <0.0001 0.34 (0.19-0.60) 0.0002
HOMA-IR 1.0 (0.97-1.1) 0.33   
  1. : 95% confidence interval; PNPLA3, patatin-like phospholipase domain-containing protein 3; HOMA-IR, homeostasis model assessment insulin resistance.