hTERT promoter polymorphism, -1327C>T, is associated with the risk of epithelial cancer

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Table 4 Association between the −1327 C>T hTERT genotype and the risks of various types of malignancies in autopsy cases

Genotype	Lung cancer^a (n = 167)				Colorectal cancer^a (n = 147)				Latent prostate cancer^a (n = 89)
	Crude OR (95% CI)	p-value	Adjusted OR^b (95% CI)	p-value	Crude OR (95% CI)	p-value	Adjusted OR^b (95% CI)	p-value	Crude OR (95% CI)	p-value	Adjusted OR^b (95% CI)	p-value
CC	1 (reference)		1 (reference)		1 (reference)		1 (reference)		1 (reference)		1 (reference)
CT	0.92	0.67	0.97	0.88	0.91	0.64	0.87	0.50	0.57	0.030	0.56	0.046
	(0.65 - 1.32)		(0.65 – 1.44)		(0.63 - 1.33)		(0.58 – 1.30)		(0.34 - 0.95)		(0.31 – 0.99)
TT	0.47	0.022	0.48	0.038	0.38	0.0081	0.39	0.0012	0.38	0.025	0.27	0.0083
	(0.23 - 0.90)		(0.23 – 0.96)		(0.16 - 0.79)		(0.17 – 0.82)		(0.14 - 0.89)		(0.078 – 0.73)
Dominant model ^c	0.83	0.28	0.86	0.44	0.80	0.23	0.76	0.17	0.53	0.0090	0.49	0.0088
	(0.59 - 1.17)		(0.59 – 1.26)		(0.56 - 1.15)		( 0.51 – 1.12)		(0.33 - 0.85)		(0.28 – 0.84)
Recessive model ^d	0.49	0.024	0.49	0.032	0.40	0.0085	0.42	0.015	0.49	0.089	0.35	0.030
	(0.24 - 0.91)		(0.24 – 0.94)		(0.17 - 0.81)		(0.18 – 0.86)		(0.18 - 1.11)		(0.10 – 0.91)
Additive model ^e	0.78	0.066	0.80	0.12	0.74	0.037	0.72	0.032	0.60	0.0060	0.54	0.0033
	(0.60 - 1.02)		(0.59 – 1.06)		(0.56 - 0.98)		(0.53 - 0.97)		(0.40 - 0.87)		(0.35 – 0.82)

The risk of each type of malignancy was estimated by calculating crude OR and OR adjusted for age, sex, smoking status and alcohol habit using a logistic regression model in autopsy cases (n = 1551). Significant associations highlighted in bold.
OR odds ratio, CI confidence interval.
^a Cases with each type of malignancy were compared with control (cases with no malignancy).
^bCalculated for cases for whom smoking and drinking history was available (n = 1371).
^cCT + TT vs CC.
^dTT vs CT + CC.
^eApplied by including the number of T-alleles (0,1,2) as a continuous variable in the logistic regression model.