Table 3 Association between the -1327C>T hTERT genotype and the risks of epithelial/non-epithelial malignancy in autopsy cases
From: hTERT promoter polymorphism, -1327C>T, is associated with the risk of epithelial cancer
Genotype | Genotype distribution, n(%) | Risk of epithelial malignancya | Risk of non-epithelial malignancyb | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Controlc | Epithelial malignancy | Non-epithelial malignancy | Crude OR (95% CI) | p-value | Adjusted ORd (95% CI) | p-value | Crude OR (95% CI) | p-value | Adjusted ORd (95% CI) | p-value | |
CC | 245 (41.5) | 372 (47.2) | 100 (42.6) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | ||||
CT | 272 (46.0) | 343 (43.5) | 102 (43.4) | 0.83 | 0.11 | 0.83 | 0.13 | 0.92 | 0.61 | 0.90 | 0.58 |
(0.66 - 1.04) | (0.65 - 1.06) | (0.66 - 1.27) | (0.63 - 1.29) | ||||||||
TT | 74 (12.5) | 73 (9.3) | 33 (14.0) | 0.65 | 0.020 | 0.61 | 0.012 | 1.09 | 0.71 | 0.94 | 0.80 |
(0.45 - 0.93) | (0.42 - 0.90) | (0.68 - 1.74) | (0.55 - 1.56) | ||||||||
Dominant model | |||||||||||
CC | 245 (41.5) | 372 (47.2) | 100 (42.6) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | ||||
CT + TT | 346 (58.5) | 416 (52.8) | 135 (57.4) | 0.79 | 0.033 | 0.78 | 0.033 | 0.96 | 0.77 | 0.91 | 0.58 |
(0.64 - 0.98) | (0.62 - 0.98) | (0.70 - 1.30) | (0.65 - 1.27) | ||||||||
Recessive model | |||||||||||
CC + CT | 517 (87.5) | 715 (90.7) | 202 (86.0) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | ||||
TT | 74 (12.5) | 73 (9.3) | 33 (14.0) | 0.71 | 0.054 | 0.68 | 0.033 | 1.14 | 0.56 | 0.98 | 0.95 |
(0.51 - 1.01) | (0.47 - 0.97) | (0.73 - 1.76) | (0.60 - 1.59) | ||||||||
Additive model e | |||||||||||
0.81 | 0.012 | 0.80 | 0.0096 | 1.01 | 0.94 | 0.95 | 0.67 | ||||
(0.69 - 0.96) | (0.67 - 0.95) | (0.81 - 1.26) | (0.74 - 1.21) | ||||||||