hTERT promoter polymorphism, -1327C>T, is associated with the risk of epithelial cancer

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Table 2 Association between the -1327C>T hTERT genotype and the risk of overall malignancy in autopsy cases

	Genotype distribution, n (%)			Risk for malignancy^a				Risk for multiple malignancies^b
	Control^c	Single malignancy cases	Multiple malignancy cases	Crude OR (95% CI)	p-value	Adjusted OR^d (95% CI)	p-value	Crude OR (95% CI)	p-value	Adjusted OR^d (95% CI)	p-value
CC	245 (41.5)	308 (43.3)	130 (52.2)	1 (reference)		1 (reference)		1 (reference)		1 (reference)
CT	272 (46.0)	324 (45.6)	100 (40.2)	0.87	0.22	0.86	0.22	0.69	0.021	0.68	0.024
				(0.70 - 1.08)		(0.68 - 1.09)		(0.51 - 0.95)		(0.548- 0.95)
TT	74 (12.5)	79 (11.1)	19 (7.6)	0.74	0.085	0.68	0.041	0.48	0.0065	0.46	0.0046
				(0.53 - 1.04)		(0.48 - 0.98)		(0.27 - 0.82)		(0.25 - 0.79)
Dominant model
CC	245 (41.5)	308 (43.3)	130 (52.2)	1 (reference)		1 (reference)		1 (reference)		1 (reference)
CT + TT	346 (58.5)	403 (56.7)	119 (47.8)	0.84	0.11	0.82	0.087	0.65	0.0043	0.63	0.0040
				(0.69 - 1.04)		(0.66 - 1.03)		(0.48 - 0.87)		(0.45 - 0.86)
Recessive model
CC + CT	517 (87.5)	632 (88.9)	230 (92.4)	1 (reference)		1 (reference)		1 (reference)		1 (reference)
TT	74 (12.5)	79 (11.1)	19 (7.6)	0.79	0.16	0.73	0.080	0.58	0.033	0.55	0.024
				(0.58 - 1.10)		(0.53 - 1.04)		(0.33 - 0.96)		(0.31 - 0.93)
Additive model ^e				0.86	0.063	0.70	0.036	0.69	0.0017	0.67	0.0014
				(0.74 - 1.01)		(0.51 - 0.98)		(0.55 - 0.87)		(0.53 - 0.86)

The risk of malignancy was estimated by calculating crude OR and OR adjusted for age, sex, smoking status and alcohol habit using a logistic regression model in autopsy cases (n = 1551). Significant associations highlighted in bold.
OR odds ratio, CI confidence interval.
^aCases with at least one malignancy were compared with control.
^bCases with more than two malignancies were compared with control.
^cCases with no malignancy (n = 591).
^dCalculated for cases for whom smoking and drinking history was available (n = 1371).
^eApplied by including the number of T-alleles (0,1,2) as a continuous variable in the logistic regression model.