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Table 3 Association of age, menopausal status, BMI, family history of breast cancer, parity and use of hormonal replacement therapy with PD measures obtained with DM-Scan (3 raters) and with Cumulus (one rater)

From: Validation of DM-Scan, a computer-assisted tool to assess mammographic density in full-field digital mammograms

Variables N DM-Scan (Rater 1) DM-Scan (Rater2) DM-Scan (Rater 3) Cumulus (Rater 1)
beta 95% CIa P-value beta 95% CI P-value beta 95% CIa P-value beta 95% CIa P-value
Age              
  <55 192 Ref.    Ref    Ref    Ref   
  55-59 225 -3.3 -5.8 to -0.7 0.011 -4.6 -7.2 to -2.1 <0.001 -3.6 -6.1 to -1.1 0.004 -3.6 -6.1 to -1.2 0.003
  >=60 221 -4.9 -7.5 to -2.3 <0.001 -5.9 -8.6 to -3.3 <0.001 -5.1 -7.7 to -2.5 <0.001 -5.2 -7.7 to -2.7 <0.001
  per 5 years   -2.8 -4.0 to -1.6 <0.001 -3.2 -4.5 to -2.0 <0.001 -2.7 -3.8 to -1.5 <0.001 -3.1 -4.2 to -1.9 <0.001
Menopause              
  Yes 570 Ref    Ref    Ref    Ref   
  No 68 +1.0 -2.3 to +4.2 0.568 +1.9 -1.4 to +5.2 0.251 +0.6 -2.6 to +3.8 0.721 +0.5 -2.8 to +3.7 0.774
BMI              
  <25 146 Ref.    Ref    Ref    Ref   
  25-29.9 285 -7.2 -9.7 to -4.7 <0.001 -7.2 -9.7 to -4.6 <0.001 -6.5 -8.9 to -4.1 <0.001 -7.9 -10.3 to -5.5 <0.001
  30-34.9 207 -14.2 -16.8 to -11.6 <0.001 -14.3 -16.9 to -11.6 <0.001 -13.4 -15.9 to -10.8 <0.001 -13.5 -16.0 to -11.0 <0.001
  per 1 unit   -1.1 -1.3 to -1.0 <0.001 -1.2 -1.4 to –1.0 <0.001 -1.1 -1.3 to -0.9 <0.001 -1.0 -1.2 to -0.9 <0.001
First-degree relative with breast cancer              
  No 600 Ref.    Ref    Ref    Ref   
  Yes 38 +3.9 +0.0 to +7.7 0.050 +5.1 +1.2 to +9.0 0.010 +5.4 +1.6 to +9.2 0.006 +5.6 +1.9 to +9.4 0.003
Parity              
  None 49 Ref    Ref    Ref    Ref   
  1 78 -1.7 -6.1 to 2.6 0.439 -1.3 -5.8 to +3.1 0.552 -3.7 -8.0 to +0.6 0.093 -1.1 -5.3 to +3.3 0.616
  2 297 -4.5 -8.2 to -0.8 0.018 -3.1 -6.9 to +0.7 0.109 -5.0 -8.7 to -1.4 0.007 -2.1 -5.7 to +1.5 0.244
  3 167 -5.3 -9.3 to -1.4 0.008 -3.7 -7.7 to +0.3 0.069 -5.7 -9.5 to -1.8 0.004 -3.3 -7.1 to +0.5 0.092
  >=4 47 -8.3 -13.2 to -3.4 0.001 -5.4 -10.3 to -0.4 0.035 -8.5 -13.3 to -3.7 0.001 -5.0 -9.7 to -0.2 0.041
  per birth   -1.9 -2.9 to -1.0 <0.001 -1.3 -2.2 to -0.3 0.010 -1.7 -2.7 to -0.8 <0.001 -1.2 -2.2 to -0.3 0.008
Hormonal Replacement              
  Treatment              
  Never 573 Ref    Ref    Ref    Ref   
  Ever (Current + Past) 7+58 +0.1 -2.9 to +3.2 0.946 +1.2 -1.9 to +4.3 0.438 +0.9 -2.1 to +3.9 0.540 +1.5 -1.5 to +4.5 0.331
  1. a 95% Confidence interval.