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Table 3 Association of age, menopausal status, BMI, family history of breast cancer, parity and use of hormonal replacement therapy with PD measures obtained with DM-Scan (3 raters) and with Cumulus (one rater)

From: Validation of DM-Scan, a computer-assisted tool to assess mammographic density in full-field digital mammograms

Variables

N

DM-Scan (Rater 1)

DM-Scan (Rater2)

DM-Scan (Rater 3)

Cumulus (Rater 1)

beta

95% CIa

P-value

beta

95% CI

P-value

beta

95% CIa

P-value

beta

95% CIa

P-value

Age

             

  <55

192

Ref.

  

Ref

  

Ref

  

Ref

  

  55-59

225

-3.3

-5.8 to -0.7

0.011

-4.6

-7.2 to -2.1

<0.001

-3.6

-6.1 to -1.1

0.004

-3.6

-6.1 to -1.2

0.003

  >=60

221

-4.9

-7.5 to -2.3

<0.001

-5.9

-8.6 to -3.3

<0.001

-5.1

-7.7 to -2.5

<0.001

-5.2

-7.7 to -2.7

<0.001

  per 5 years

 

-2.8

-4.0 to -1.6

<0.001

-3.2

-4.5 to -2.0

<0.001

-2.7

-3.8 to -1.5

<0.001

-3.1

-4.2 to -1.9

<0.001

Menopause

             

  Yes

570

Ref

  

Ref

  

Ref

  

Ref

  

  No

68

+1.0

-2.3 to +4.2

0.568

+1.9

-1.4 to +5.2

0.251

+0.6

-2.6 to +3.8

0.721

+0.5

-2.8 to +3.7

0.774

BMI

             

  <25

146

Ref.

  

Ref

  

Ref

  

Ref

  

  25-29.9

285

-7.2

-9.7 to -4.7

<0.001

-7.2

-9.7 to -4.6

<0.001

-6.5

-8.9 to -4.1

<0.001

-7.9

-10.3 to -5.5

<0.001

  30-34.9

207

-14.2

-16.8 to -11.6

<0.001

-14.3

-16.9 to -11.6

<0.001

-13.4

-15.9 to -10.8

<0.001

-13.5

-16.0 to -11.0

<0.001

  per 1 unit

 

-1.1

-1.3 to -1.0

<0.001

-1.2

-1.4 to –1.0

<0.001

-1.1

-1.3 to -0.9

<0.001

-1.0

-1.2 to -0.9

<0.001

First-degree relative with breast cancer

             

  No

600

Ref.

  

Ref

  

Ref

  

Ref

  

  Yes

38

+3.9

+0.0 to +7.7

0.050

+5.1

+1.2 to +9.0

0.010

+5.4

+1.6 to +9.2

0.006

+5.6

+1.9 to +9.4

0.003

Parity

             

  None

49

Ref

  

Ref

  

Ref

  

Ref

  

  1

78

-1.7

-6.1 to 2.6

0.439

-1.3

-5.8 to +3.1

0.552

-3.7

-8.0 to +0.6

0.093

-1.1

-5.3 to +3.3

0.616

  2

297

-4.5

-8.2 to -0.8

0.018

-3.1

-6.9 to +0.7

0.109

-5.0

-8.7 to -1.4

0.007

-2.1

-5.7 to +1.5

0.244

  3

167

-5.3

-9.3 to -1.4

0.008

-3.7

-7.7 to +0.3

0.069

-5.7

-9.5 to -1.8

0.004

-3.3

-7.1 to +0.5

0.092

  >=4

47

-8.3

-13.2 to -3.4

0.001

-5.4

-10.3 to -0.4

0.035

-8.5

-13.3 to -3.7

0.001

-5.0

-9.7 to -0.2

0.041

  per birth

 

-1.9

-2.9 to -1.0

<0.001

-1.3

-2.2 to -0.3

0.010

-1.7

-2.7 to -0.8

<0.001

-1.2

-2.2 to -0.3

0.008

Hormonal Replacement

             

  Treatment

             

  Never

573

Ref

  

Ref

  

Ref

  

Ref

  

  Ever (Current + Past)

7+58

+0.1

-2.9 to +3.2

0.946

+1.2

-1.9 to +4.3

0.438

+0.9

-2.1 to +3.9

0.540

+1.5

-1.5 to +4.5

0.331

  1. a 95% Confidence interval.