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Table 6 Abdominal adiposity and breast cancer risk in postmenopausal women not currently using hormone therapy by current BMI

From: Body size, modifying factors, and postmenopausal breast cancer risk in a multiethnic population: the San Francisco Bay Area Breast Cancer Study

 

Current BMI < 25.0kg/m2

Current BMI ≥ 25.0kg/m2

 

All breast cancer

Cases (n=396)

Controls (n=648)

OR a 95% CI

Cases (n=402)

Controls (n=680)

OR a 95% CI

P interaction

Waist (cm) b

       

 M1: ≤ 90.5

151

272

1.00

140

321

0.87 0.65-1.18

0.25

 M2: > 90.5

27

26

1.90 1.05-3.44

387

585

1.21 0.93-1.57

 

Waist-to-height ratio b

       

 M1: ≤ 0.58

156

276

1.00

152

310

0.93 0.69-1.24

0.93

 M2: > 0.58

22

22

1.87 0.98-3.56

375

596

1.17 0.90-1.52

 

ER+PR+ breast cancer

Cases (n=194)

Controls (n=648)

OR a 95% CI

Cases (n=220)

Controls (n=680)

OR a 95% CI

P interaction

Waist (cm) b

       

 M1: ≤ 90.5

73

272

1.00

67

321

0.92 0.62-1.36

0.16

 M2: > 90.5

10

26

1.53 0.69-3.39

213

585

1.55 1.11-2.17

 

Waist-to-height ratio b

       

 M1: ≤ 0.58

75

276

1.00

75

310

1.02 0.70-1.50

0.47

 M2: > 0.58

8

22

1.53 0.63-3.68

205

596

1.52 1.08-2.12

 
  1. Abbreviations: BMI, body mass index; CI, confidence interval; ER+, estrogen receptor–positive; OR, odds ratio; PR+, progesterone receptor–positive.
  2. a OR and 95% CI adjusted for age (years, continuous), race/ethnicity (non-Hispanic White, African American, Hispanic), place of birth (US-born, foreign-born), education (some high school or less, high school or vocational/technical school graduate, some college, college graduate), family history of breast cancer in first-degree relatives (no, yes), personal history of biopsy-confirmed benign breast disease (no, yes), age at menarche (≤11, 12, 13, ≥14 years), number of full-term pregnancies (nulliparous, 1, 2, 3, ≥4), age at first full-term pregnancy (nulliparous, ≤19, 20–24, 25–29, ≥30 years), lifetime breast-feeding (nulliparous, 0, ≤6, 7–12, 13–24, ≥25 months), lifetime physical activity (quartiles, hours/week), alcohol consumption in reference year (0, 0.1-4.9, 5–9.9, 10–19.9, ≥20 g/day), and total caloric intake (quartiles, kcal/day).
  3. b Based on median among all postmenopausal controls.
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