Skip to main content
SpringerPlus

Table 3 BMI and weight gain and breast cancer risk in postmenopausal women not currently using hormone therapy by race/ethnicity a and estrogen receptor and progesterone receptor status

From: Body size, modifying factors, and postmenopausal breast cancer risk in a multiethnic population: the San Francisco Bay Area Breast Cancer Study

 

All race/ethnicities

Hispanics

African Americans

Non-Hispanic Whites

All breast cancer

Cases (n = 801)

Controls (n = 1,336)

OR b 95% CI

Cases (n = 377)

Controls (n = 709)

OR c 95% CI

Cases (n = 243)

Controls (n = 315)

OR c 95% CI

Cases (n = 181)

Controls (n = 312)

OR c 95% CI

Current BMI (kg/m2) d

            

 <25.0

208

329

1.0

81

119

1.0

51

70

1.0

76

140

1.0

 25.0-29.9

278

476

0.95 0.74-1.21

133

273

0.78 0.54-1.14

90

106

1.19 0.74-1.94

55

97

0.90 0.56-1.43

 ≥30.0

312

523

0.94 0.74-1.20

161

312

0.77 0.53-1.12

101

137

1.07 0.66-1.73

50

74

1.19 0.72-1.99

   

Ptrend = 0.64

  

Ptrend = 0.24

  

Ptrend = 0.88

  

Ptrend = 0.58

Current BMI (kg/m2) –adjusted for weight gain d,e

            

 <25.0

  

1.0

  

1.0

  

1.0

  

1.0

 25.0-29.9

  

0.90 0.67-1.20

  

0.80 0.52-1.25

  

1.25 0.70-2.26

  

0.63 0.34-1.16

 ≥30.0

  

0.79 0.56-1.13

  

0.73 0.43-1.24

  

1.15 0.57-2.30

  

0.52 0.22-1.22

   

Ptrend = 0.75

  

Ptrend = 0.26

  

Ptrend = 0.77

  

Ptrend = 0.11

Young-adult BMI (kg/m2) f,g

            

 T1: ≤21.2

286

402

1.0

109

161

1.0

93

122

1.0

84

119

1.0

 T2: 21.3-23.7

259

411

0.87 0.69-1.09

122

209

0.85 0.60-1.20

77

90

1.17 0.76-1.79

60

112

0.65 0.41-1.02

 T3: >23.7

216

445

0.68 0.54-0.86

115

272

0.63 0.45-0.90

67

98

0.93 0.59-1.45

34

75

0.52 0.30-0.90

   

Ptrend < 0.01

  

Ptrend = 0.01

  

Ptrend = 0.80

  

Ptrend = 0.01

Weight gain (kg) h,i

78

140

          

 Stable j

180

291

1.0

36

65

1.0

18

26

1.0

24

49

1.0

 Gain, 3.0-9.9

217

376

1.15 0.82-1.63

82

149

1.05 0.63-1.76

50

55

1.27 0.59-2.73

48

87

1.27 0.67-2.43

 Gain, 10.0-19.9

142

247

1.06 0.76-1.48

101

217

0.88 0.54-1.45

68

80

1.18 0.57-2.44

48

79

1.36 0.71-2.62

 Gain, 20.0-29.9

111

154

1.03 0.72-1.48

71

125

1.04 0.61-1.78

44

72

0.91 0.43-1.93

27

50

1.19 0.57-2.48

 Gain, ≥30.0

  

1.19 0.81-1.75

38

67

0.91 0.50-1.66

51

64

1.13 0.54-2.39

22

23

2.63 1.12-6.19

   

Ptrend = 0.75

  

Ptrend = 0.75

  

Ptrend = 0.75

  

Ptrend = 0.10

Weight gain (kg) – adjusted for current BMI h,i,k

            

 Stable j

  

1.0

  

1.0

  

1.0

  

1.0

 Gain, 3.0-9.9

  

1.17 0.83-1.65

  

1.07 0.64-1.80

  

1.17 0.54-2.56

  

1.38 0.71-2.67

 Gain, 10.0-19.9

  

1.14 0.79-1.65

  

1.00 0.58-1.70

  

1.00 0.45-2.24

  

1.92 0.89-4.15

 Gain, 20.0-29.9

  

1.17 0.77-1.78

  

1.22 0.66-2.25

  

0.76 0.32-1.85

  

1.94 0.75-5.03

 Gain, ≥30.0

  

1.41 0.88-2.26

  

1.12 0.55-2.27

  

0.99 0.39-2.49

  

4.70 1.48-14.97

   

Ptrend = 0.24

  

Ptrend = 0.67

  

Ptrend = 0.68

  

Ptrend = 0.02

ER+PR+ breast cancer

Cases (n = 415)

Controls (n = 1,336)

OR b 95% CI

Cases (n = 191)

Controls (n = 709)

OR c 95% CI

Cases (n = 108)

Controls (n = 315)

OR c 95% CI

Cases (n = 116)

Controls (n = 312)

OR c 95% CI

Current BMI (kg/m2) d

            

 <25.0

98

329

1.0

34

119

1.0

19

70

1.0

45

140

1.0

 25.0-29.9

141

476

1.09 0.80-1.49

60

273

0.90 0.54-1.49

44

106

1.76 0.89-3.47

37

97

1.06 0.61-1.85

 ≥30.0

175

523

1.30 0.95-1.78

96

312

1.23 0.75-2.01

45

137

1.46 0.74-2.89

34

74

1.39 0.76-2.55

   

Ptrend = 0.09

  

Ptrend = 0.22

  

Ptrend = 0.40

  

Ptrend = 0.30

Current BMI (kg/m2) – adjusted for weight gain d,e

            

 <25.0

  

1.0

  

1.0

  

1.0

  

1.0

 25.0-29.9

  

1.06 0.73-1.54

  

1.01 0.56-1.84

  

1.77 0.78-4.06

  

0.74 0.35-1.56

 ≥30.0

  

1.01 0.64-1.60

  

1.17 0.58-2.35

  

1.29 0.48-3.48

  

0.64 0.23-1.76

   

Ptrend = 0.99

  

Ptrend = 0.62

  

Ptrend = 0.78

  

Ptrend = 0.37

Young-adult BMI (kg/m2) f,g

            

 T1: ≤21.2

147

402

1.0

51

161

1.0

45

122

1.0

51

119

1.0

 T2: 21.3-23.7

133

411

0.87 0.65-1.15

58

209

0.87 0.55-1.37

35

90

1.23 0.69-2.20

40

112

0.66 0.38-1.15

 T3: >23.7

116

445

0.73 0.54-0.98

65

272

0.80 0.51-1.25

28

98

0.73 0.39-1.36

23

75

0.52 0.27-1.00

   

Ptrend = 0.04

  

Ptrend = 0.33

  

Ptrend = 0.39

  

Ptrend = 0.04

Weight gain (kg) h,l

            

 Stable j

44

140

1.0

18

65

1.0

9

26

1.0

17

49

1.0

 Gain, 3.0-9.9

79

291

0.94 0.61-1.46

32

149

0.80 0.41-1.58

20

55

1.11 0.40-3.14

27

87

1.02 0.48-2.18

 Gain, 10.0-19.9

114

376

1.07 0.71-1.62

55

217

1.00 0.53-1.88

26

80

0.96 0.36-2.57

33

79

1.48 0.70-3.15

 Gain, 20.0-29.9

77

247

1.12 0.72-1.74

34

125

1.02 0.52-2.03

25

72

1.19 0.44-3.18

18

50

1.29 0.55-3.04

 Gain, ≥30.0

67

154

1.53 0.96-2.45

29

67

1.43 0.70-2.94

24

64

1.27 0.47-3.42

14

23

2.56 0.95-6.88

   

Ptrend = 0.04

  

Ptrend = 0.16

  

Ptrend = 0.58

  

Ptrend = 0.07

Weight gain (kg) – adjusted for current BMI h,k,l

            

 Stable j

  

1.0

  

1.0

  

1.0

  

1.0

 Gain, 3.0-9.9

  

0.93 0.60-1.44

  

0.81 0.41-1.59

  

0.92 0.31-2.67

  

1.09 0.50-2.38

 Gain, 10.0-19.9

  

1.04 0.66-1.65

  

0.96 0.49-1.89

  

0.67 0.22-2.04

  

1.90 0.77-4.73

 Gain, 20.0-29.9

  

1.10 0.65-1.86

  

0.93 0.43-2.05

  

0.85 0.26-2.77

  

1.80 0.58-5.63

 Gain, ≥30.0

  

1.53 0.85-2.73

  

1.29 0.55-3.01

  

1.02 0.29-3.58

  

3.82 0.99-14.71

Ptrend = 0.13

Ptrend = 0.48

Ptrend = 0.90

Ptrend = 0.06

  1. Abbreviations: BMI, body mass index; CI, confidence interval; ER+, estrogen receptor–positive; OR, odds ratio; PR+, progesterone receptor–positive.
  2. a All P values for interaction by race/ethnicity were >0.05.
  3. b Adjusted for age (years, continuous), race/ethnicity (non-Hispanic White, African American, Hispanic), place of birth (U.S.-born, foreign-born), education (some high school or less, high school or vocational/technical school graduate, some college, college graduate), first-degree family history of breast cancer (no, yes), personal history of biopsy-confirmed benign breast disease (no, yes), age at menarche (≤11, 12, 13, ≥14 years), number of full-term pregnancies (nulliparous, 1, 2, 3, ≥4), age at first full-term pregnancy (nulliparous, ≤19, 20–24, 25–29, ≥30 years), lifetime breast-feeding (nulliparous, 0, ≤6, 7–12, 13–24, ≥25 months), lifetime physical activity (quartiles, hours/week), alcohol consumption in reference year (0, 0.1-4.9, 5–9.9, 10–19.9, ≥20 g/day), and total caloric intake (quartiles, kcal/day).
  4. c Not adjusted for race/ethnicity.
  5. d Based on self-reported weight and measured height at interview (if not available, then based on measured weight at interview and/or self-reported height).
  6. e Adjusted for above variables, and weight gain.
  7. f Based on tertiles among all postmenopausal controls.
  8. g Based on self-reported young-adult weight and measured height at interview (or self-reported adult height when measured height not available).
  9. h Self-reported weight (or measured weight at interview if self-reported weight not available) minus self-reported young-adult weight.
  10. i Excludes 34 cases and 55 controls who lost >3 kg of weight.
  11. j Stable weight defined as +/- 3 kg.
  12. k Adjusted for above variables, and current BMI.
  13. l Excludes 15 ER+PR+ cases and 55 controls who lost >3 kg of weight.
Back to article page