Table 4 Point estimate and 90% confidence interval for the geometric mean ratios of C max , AUC (0-t) and AUC (0-inf) for THC/CBD spray in combination with rifampicin, ketoconazole and omeprazole
90% confidence limits | ||||
|---|---|---|---|---|
Analyte/PK variable | Number of subjects | Estimate | Lower | Upper |
Rifampicin and THC/CBD spray | ||||
THC/Cmax | 12 | 0.614 | 0.525 | 0.719 |
THC/AUC(0-t) | 12 | 0.711 | 0.617 | 0.820 |
THC/AUC(0-inf) | 11 | 0.761 | 0.667 | 0.868 |
CBD/Cmax | 12 | 0.480 | 0.420 | 0.550 |
CBD/AUC(0-t) | 12 | 0.381 | 0.274 | 0.529 |
CBD/AUC(0-inf) | 10 | 0.422 | 0.265 | 0.673 |
11-OH-THC/Cmax | 12 | 0.140 | 0.120 | 0.163 |
11-OH-THC/AUC(0-t) | 12 | 0.099 | 0.088 | 0.113 |
11-OH-THC/AUC(0-inf) | 11 | 0.131 | 0.115 | 0.150 |
Ketoconazole and THC/CBD spray | ||||
THC/Cmax | 11 | 1.252 | 1.043 | 1.503 |
THC/AUC(0-t) | 11 | 1.770 | 1.385 | 2.263 |
THC/AUC(0-inf) | 10 | 1.840 | 1.446 | 2.342 |
CBD/Cmax | 11 | 1.961 | 1.497 | 2.569 |
CBD/AUC(0-t) | 11 | 2.715 | 2.047 | 3.601 |
CBD/AUC(0-inf) | 9 | 1.923 | 1.560 | 2.370 |
11-OH-THC/Cmax | 11 | 3.074 | 2.705 | 3.493 |
11-OH-THC/AUC(0-t) | 11 | 3.823 | 3.405 | 4.292 |
11-OH-THC/AUC(0-inf) | 10 | 3.616 | 3.181 | 4.111 |
Omeprazole and THC/CBD spray | ||||
THC/Cmax | 12 | 1.125 | 0.842 | 1.501 |
THC/AUC(0-t) | 12 | 0.964 | 0.643 | 1.445 |
THC/AUC(0-inf) | 12 | 0.962 | 0.668 | 1.386 |
CBD/Cmax | 12 | 1.320 | 0.938 | 1.859 |
CBD/AUC(0-t) | 12 | 1.326 | 0.756 | 2.325 |
CBD/AUC(0-inf) | 11 | 1.096 | 0.745 | 1.611 |
11-OH-THC/Cmax | 12 | 0.866 | 0.700 | 1.073 |
11-OH-THC/AUC(0-t) | 12 | 0.869 | 0.629 | 1.201 |
11-OH-THC/AUC(0-inf) | 12 | 0.869 | 0.641 | 1.179 |