Table 3 Summary of pharmacokinetic parameters of THC, CBD and 11-OH-THC after a single dose of THC/CBD (4 sprays) alone or in combination omeprazole
Parameter | THC/CBD spray alone (n = 12) | THC/CBD spray and omeprazole (n = 12) |
|---|---|---|
THC | ||
AUC(0-t) (h*ng/mL) | 8.76 (8.62) | 7.41 (4.75) |
AUC(0-inf) (h*ng/mL) | 9.39 (8.81) | 8.10 (4.78) |
Cmax (ng/mL) | 2.50 (1.85) | 2.48 (1.06) |
Tmax (h) | 1.25 (0.77-3.02) | 1.25 (1.00-1.75) |
Kel (h-1) | 0.305 (0.109) | 0.357 (0.218) |
t½ (h) | 2.65 (1.25) | 2.37 (0.92) |
CL/F (L/h) | 2161 (1990) | 2284 (2520) |
Varea/F (L) | 6889 (5296) | 6052 (3384) |
CBD | ||
AUC(0-t) (h*ng/mL) | 1.83 (1.19) | 2.25 (1.51) |
AUC(0-inf) (h*ng/mL) | 3.00 (1.43)a | 3.33 (1.77) |
Cmax (ng/mL) | 0.63 (0.43) | 0.73 (0.30) |
Tmax (h) | 1.15 (0.50-3.02) | 1.25 (0.48-1.75) |
Kel (h-1) | 0.224 (0.158)a | 0.210 (0.114) |
t½ (h) | 5.22 (4.51)a | 5.46 (6.13) |
CL/F (L/h) | 4741 (3845)a | 4772 (4550) |
Varea/F (L) | 26298 (14532)a | 24757 (16311) |
11-OH-THC | ||
AUC(0-t) (h*ng/mL) | 21.52 (14.76) | 17.69 (9.05) |
AUC(0-inf) (h*ng/mL) | 24.17 (16.47) | 19.80 (9.74) |
Cmax (ng/mL) | 3.48 (2.27) | 2.84 (1.40) |
Tmax (h) | 2.00 (1.25-3.02) | 1.52 (1.23-2.50) |
Kel (h-1) | 0.114 (0.062) | 0.095 (0.029) |
t½ (h) | 7.30 (2.87) | 7.98 (2.82) |