Figure 2From: A Phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteers Mean (+ SD ) plasma concentrations of THC ( a ), CBD (b) and 11- OH- THC ( c ) over time after administration of a single dose ( 4 sprays ) of THC/ CBD ( n = 11 ) or THC/ CBD spray in combination with multiple dose ( 2 x 200 mg ) administration of Ketoconazole ( n = 11). Back to article page