An omnibus permutation test on ensembles of two-locus analyses can detect pure epistasis and genetic heterogeneity in genome-wide association studies

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Table 8 Four-locus penetrances that lead to the heritability of 0.01

AA, BB, CC and DD denote homozygous wild-type genotypes. Aa, Bb, Cc and Dd denote heterozygous genotypes. aa, bb, cc and dd denote homozygous variant genotypes. All allele frequencies are equal (p _A = p _B = p _C = p _D = 0.5). K = 1/3501.