Skip to main content

Table 7 Three-locus penetrances that lead to the heritability of 0.01

From: An omnibus permutation test on ensembles of two-locus analyses can detect pure epistasis and genetic heterogeneity in genome-wide association studies

  

Penetrance of genotype

 
 

CC

Cc

cc

Genotype

BB

Bb

bb

BB

Bb

bb

BB

Bb

bb

AA

0

0

16K

0

0

0

0

0

0

Aa

0

0

0

0

4K

0

0

0

0

aa

0

0

0

0

0

0

16K

0

0

  1. AA, BB and CC denote homozygous wild-type genotypes. Aa, Bb and Cc denote heterozygous genotypes. aa, bb and cc denote homozygous variant genotypes. All allele frequencies are equal (p A = p B = p C = 0.5). K = 1/901.