Table 3 Statistical power of 2LOmb to detect genetic heterogeneity in large-scaled simulated data sets with different numbers of available SNPs, different sample sizes and different ratios of case samples from two affected groups where the affected status is governed by a two-locus interaction
| Â | Â | Statistical power | |||
|---|---|---|---|---|---|
| Â | Â | 10,000 SNPs | 100,000 SNPs | ||
| Â | Ratio | At least | Two | At least | Two |
Sample | of case | one interaction | interactions | one interaction | interactions |
size | samples | detected | detected | detected | detected |
1,600 | 1:3 | 1.00 | 0.30 | 1.00 | 0.13 |
| Â | 1:1 | 1.00 | 1.00 | 1.00 | 1.00 |
3,200 | 1:3 | 1.00 | 0.98 | 1.00 | 0.92 |
| Â | 1:1 | 1.00 | 1.00 | 1.00 | 1.00 |
6,400 | 1:3 | 1.00 | 1.00 | 1.00 | 1.00 |
| Â | 1:1 | 1.00 | 1.00 | 1.00 | 1.00 |