Table 2 Statistical power of 2LOmb to detect genetic heterogeneity in small-scaled simulated data sets with different numbers of available SNPs, different numbers of causative SNPs and different ratios of case samples from two affected groups
| Â | Â | Statistical power | |||
|---|---|---|---|---|---|
| Â | Â | 20 SNPs | 1,000 SNPs | ||
Number of | Ratio | At least | Two | At least | Two |
causative | of case | one interaction | interactions | one interaction | interactions |
SNPs | samples | detected | detected | detected | detected |
2&2 | 1:3 | 1.00 | 0.95 | 1.00 | 0.55 |
| Â | 1:1 | 1.00 | 1.00 | 1.00 | 1.00 |
3&3 | 1:3 | 1.00 | 1.00 | 1.00 | 0.88 |
| Â | 1:1 | 1.00 | 1.00 | 1.00 | 1.00 |
4&4 | 1:3 | 1.00 | 1.00 | 1.00 | 1.00 |
| Â | 1:1 | 1.00 | 1.00 | 1.00 | 1.00 |
2&3 | 1:3 | 1.00 | 0.93 | 1.00 | 0.60 |
| Â | 1:1 | 1.00 | 1.00 | 1.00 | 1.00 |
| Â | 3:1 | 1.00 | 0.98 | 1.00 | 0.94 |
2&4 | 1:3 | 1.00 | 0.94 | 1.00 | 0.63 |
| Â | 1:1 | 1.00 | 1.00 | 1.00 | 1.00 |
| Â | 3:1 | 1.00 | 1.00 | 1.00 | 0.99 |
3&4 | 1:3 | 1.00 | 1.00 | 1.00 | 0.88 |
| Â | 1:1 | 1.00 | 1.00 | 1.00 | 1.00 |
| Â | 3:1 | 1.00 | 1.00 | 1.00 | 0.97 |