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Table 4 Mean pharmacokinetic parameters of febuxostat in 14 healthy volunteers after oral administration of 80 mg (1x80 mg) test and reference products

From: Bioequivalance and pharmacokinetic study of febuxostat in human plasma by using LC-MS/MS with liquid liquid extraction method

Pharmacokinetic parameter

Febuxostat

Test

Reference

AUC0-t (ng · h/ml)

13774.96

14367.34

Cmax (ng/mL)

3065.46

3726.09

AUC0-∞ (ng · h/ml)

13872.24

14469.30

Kel (h_1)

0.09983

0.10996

Tmax (h)

1

1

  1. AUC0—∞: area under the curve extrapolated to infinity;
  2. AUC0—t: area under the curve up to the last sampling time;
  3. Cmax: the maximum plasma concentration;
  4. Tmax: the time to reach peak concentration;
  5. Kel: the apparent elimination rate constant.
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